RVX-297 ( RVX297 )

Catalog No. M10223 CAS No. 1044871-04-6

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

RVX-297
Note

Research use only, not for human use.
Brief Description

RVX-297 is a novel orally active, BD2 selective, BET bromodomain inhibitor.
Description

RVX-297 is a novel orally active, BD2 selective, BET bromodomain inhibitor with Alpha Screen IC50 of 0.08, 0.05 and 0.02 uM for BRD2 (BD2), BRD3 (BD2) and BRD4 (BD2), respectively; displays about 50-fold selectivity over BD1; suppresses inflammatory gene expression in multiple immune cell types in culture; reduces pro-inflammatory mediators assessed in splenic gene expression and serum proteins in LPS model of inflammation.
Synonyms

RVX297
Pathway

Chromatin/Epigenetic
Target

Bromodomain
Recptor

Bromodomain
Research Area

——
Indication

——

CAS Number

1044871-04-6
Formula Weight

423.51
Molecular Formula

C24H29N3O4
Purity

>98% (HPLC)
Solubility

——
SMILES

COC1=C(C(NC(C2=CC(C)=C(OCCN3CCCC3)C(C)=C2)=N4)=O)C4=CC(OC)=C1
Chemical Name

2-(3,5-dimethyl-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-5,7-dimethoxyquinazolin-4(3H)-one

1. Kharenko OA, et al. Biochem Biophys Res Commun. 2016 Aug 12;477(1):62-7.

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