TPOP146 ( TPOP-146;TPOP 146 )

Catalog No. M13144 CAS No. 2018300-62-2

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

TPOP146
Note

Research use only, not for human use.
Brief Description

A potent and selective CBP/p300 bromodomain inhibitor with Kd of 134 nM for CBP bromodomain.
Description

A potent and selective CBP/p300 bromodomain inhibitor with Kd of 134 nM for CBP bromodomain, displays excellent selectivity over other bromodomains (>30-fold over BRD4 (1)); targets the CBP bromodomain in the nucleus and is capable of competing with acetyl-lysine mediated interactions of the CBP bromodomain in cellular environments.
Synonyms

TPOP-146;TPOP 146
Pathway

Chromatin/Epigenetic
Target

Bromodomain
Recptor

Bromodomain
Research Area

——
Indication

——

CAS Number

2018300-62-2
Formula Weight

481.58
Molecular Formula

C27H35N3O5
Purity

>98% (HPLC)
Solubility

DMSO
SMILES

COC1=CC(C2=CC(C(N[C@H]3CCCN(C)C3)=O)=C(OCCN(C(CC)=O)C4)C4=C2)=CC(OC)=C1
Chemical Name

1,4-Benzoxazepine-9-carboxamide, 7-(3,5-dimethoxyphenyl)-2,3,4,5-tetrahydro-N-[(3S)-1-methyl-3-piperidinyl]-4-(1-oxopropyl)-

1. Popp TA, et al. J Med Chem. 2016 Oct 13;59(19):8889-8912.

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