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TPOP146
CAS No. 2018300-62-2
TPOP146 ( TPOP-146;TPOP 146 )
Catalog No. M13144 CAS No. 2018300-62-2
A potent and selective CBP/p300 bromodomain inhibitor with Kd of 134 nM for CBP bromodomain.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameTPOP146
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NoteResearch use only, not for human use.
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Brief DescriptionA potent and selective CBP/p300 bromodomain inhibitor with Kd of 134 nM for CBP bromodomain.
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DescriptionA potent and selective CBP/p300 bromodomain inhibitor with Kd of 134 nM for CBP bromodomain, displays excellent selectivity over other bromodomains (>30-fold over BRD4 (1)); targets the CBP bromodomain in the nucleus and is capable of competing with acetyl-lysine mediated interactions of the CBP bromodomain in cellular environments.
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SynonymsTPOP-146;TPOP 146
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PathwayChromatin/Epigenetic
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TargetBromodomain
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RecptorBromodomain
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Research Area——
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Indication——
Chemical Information
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CAS Number2018300-62-2
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Formula Weight481.58
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Molecular FormulaC27H35N3O5
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Purity>98% (HPLC)
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SolubilityDMSO
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SMILESCOC1=CC(C2=CC(C(N[C@H]3CCCN(C)C3)=O)=C(OCCN(C(CC)=O)C4)C4=C2)=CC(OC)=C1
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Chemical Name1,4-Benzoxazepine-9-carboxamide, 7-(3,5-dimethoxyphenyl)-2,3,4,5-tetrahydro-N-[(3S)-1-methyl-3-piperidinyl]-4-(1-oxopropyl)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Popp TA, et al. J Med Chem. 2016 Oct 13;59(19):8889-8912.
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