GSK4027 ( GSK 4027;GSK-4027 )

Catalog No. M13238 CAS No. 2079896-25-4

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Group Booking Get Quotation Bulk Inquiry Add to Cart

Product Name

GSK4027
Note

Research use only, not for human use.
Brief Description

GSK4027 (GSK 4027, GSK-4027) is a potent, selective, cell-penetrant chemical probe of PCAF/GCN5 bromodomain with pKi of 8.9 for both.
Description

GSK4027 (GSK 4027, GSK-4027) is a potent, selective, cell-penetrant chemical probe of PCAF/GCN5 bromodomain with pKi of 8.9 for both; displays exceptional selectivity over the BET bromodomain family (>18000-fold selectivity over the BET family, >70-fold selectivity over the wider bromodomain families) and proof of cellular target engagement; GSK4027 is a useful chemical tool in elucidating the biological phenotype of PCAF/GCN5 bromodomain inhibition.
Synonyms

GSK 4027;GSK-4027
Pathway

Chromatin/Epigenetic
Target

Bromodomain
Recptor

Bromodomain
Research Area

Inflammation/Immunology
Indication

——

CAS Number

2079896-25-4
Formula Weight

377.29
Molecular Formula

C17H21BrN4O
Purity

>98% (HPLC)
Solubility

DMSO : 50 mg/mL 132.53 mM
SMILES

CN1C[C@@H](C2=CC=CC=C2)C[C@@H](NC3=C(Br)C(N(C)N=C3)=O)C1
Chemical Name

4-Bromo-2-methyl-5-(((3R,5R)-1-methyl-5-phenylpiperidin-3-yl)amino)pyridazin-3(2H)-one

1. Humphreys PG, et al. J Med Chem. 2017 Jan 26;60(2):695-709.

Calculator

molnova catalog