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RU-302

CAS No. 1182129-77-6

RU-302( [2-[(3,5-dimethyl-1,2-oxazol-4-yl)methylsulfanyl]phenyl]-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]methanone )

Catalog No. M26815 CAS No. 1182129-77-6

RU-302 is a pan inhibitor of TAM Receptor blocking the interface between the TAM Ig1 ectodomain and the Gas6 Lg domain.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 79 Get Quote
5MG 132 Get Quote
10MG 230 Get Quote
25MG 410 Get Quote
50MG 605 Get Quote
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Biological Information

  • Product Name
    RU-302
  • Note
    Research use only, not for human use.
  • Brief Description
    RU-302 is a pan inhibitor of TAM Receptor blocking the interface between the TAM Ig1 ectodomain and the Gas6 Lg domain.
  • Description
    RU-302 is a pan inhibitor of TAM Receptor blocking the interface between the TAM Ig1 ectodomain and the Gas6 Lg domain. RU-302 effectively blocks the activation of Gas6-inducible AXL and suppresses lung cancer tumor growth.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    [2-[(3,5-dimethyl-1,2-oxazol-4-yl)methylsulfanyl]phenyl]-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]methanone
  • Pathway
    Tyrosine Kinase
  • Target
    TAM Receptor
  • Recptor
    neuropeptide S receptor (NPSR)
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1182129-77-6
  • Formula Weight
    475.53
  • Molecular Formula
    C24H24F3N3O2S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (210.29 mM)
  • SMILES
    Cc1noc(C)c1CSc1ccccc1C(=O)N1CCN(CC1)c1cccc(c1)C(F)(F)F
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Batran RZ, et al. New quinolone derivatives as neuropeptide S receptor antagonists: Design, synthesis, homology modeling, dynamic simulations and modulation of Gq/Gs signaling pathways. Bioorg Chem. 2021;111:104817.
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