GSK2801

Research use only, not for human use.

GSK2801 is an effective, specific and cell active acetyl-lysine competitive inhibitor of BAZ2A(Kd: 136 nM) and BAZ2B(Kd: 257 nM) bromodomains.

GSK2801 is a A Selective Chemical Probe for BAZ2B/A bromodomains. BAZ2A/B belong to a family of ubiquitously expressed bromodomain containing proteins. Proteins of the BAZ family are characterized by a carboxy-terminal bromodomain adjacent to a PHD finger and a WACZ motif. In addition four other conserved motifs are typically found in the N-terminus of BAZ family members, namely the LH motif (a leucine-rich helical domain), the ZB2 motif and the BAZ 1 and BAZ 2 motifs. Little is known about the biological function of BAZ2B but it has been suggested to regulate nucleosome mobilization by the ATP-dependent chromatin remodeling factor ISWI.

GSK2801; GSK-2801; GSK 2801

Tyrosine Kinase

TAM Receptor

BAZ2A; BAZ2B

Others-Field

——

1619994-68-1

371.45

C20H21NO4S

98%

DMSO : 50 mg/mL. 134.61 mM; H2O : < 0.1 mg/mL

CCCOc1cc2c(cc(n2cc1)C(=O)C)c1ccccc1S(=O)(=O)C

1-(1-(2-(methylsulfonyl)phenyl)-7-propoxyindolizin-3-yl)ethanone

(-20℃)

With Ice Pack

≥ 2 years