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RO-8994
CAS No. 1309684-94-3
RO-8994( RO8994 )
Catalog No. M11239 CAS No. 1309684-94-3
A highly potent and selective, small-molecule p53-MDM2 inhibitor with HRFT IC50 of 5 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 43 | In Stock |
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| 5MG | 71 | In Stock |
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| 10MG | 116 | In Stock |
|
| 25MG | 219 | In Stock |
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| 50MG | 345 | In Stock |
|
| 100MG | 512 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameRO-8994
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NoteResearch use only, not for human use.
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Brief DescriptionA highly potent and selective, small-molecule p53-MDM2 inhibitor with HRFT IC50 of 5 nM.
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DescriptionA highly potent and selective, small-molecule p53-MDM2 inhibitor with HRFT IC50 of 5 nM; shows marked improvement in both in vitro and in vivo pharmacological properties.
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In Vitro——
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In Vivo——
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SynonymsRO8994
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PathwayApoptosis
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TargetMDM2-p53
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RecptorMdm2|P53
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1309684-94-3
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Formula Weight613.5067
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Molecular FormulaC31H31Cl2FN4O4
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 45 mg/mL
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SMILESCC(C)(C)CC1C2(C(C(N1)C(=O)NC3=C(C=C(C=C3)C(=O)N)OC)C4=C(C(=CC=C4)Cl)F)C5=C(C=C(C=C5)Cl)NC2=O
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Chemical NameSpiro[3H-indole-3,3'-pyrrolidine]-5'-carboxamide, N-[4-(aminocarbonyl)-2-methoxyphenyl]-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-1,2-dihydro-2-oxo-, (2'S,3R,4'S,5'R)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Zhang Z, et al. Bioorg Med Chem. 2014 Aug 1;22(15):4001-9.
2. Yu B, et al. Anticancer Agents Med Chem. 2016;16(10):1315-24.
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