RO-8994

CAS No. 1309684-94-3

RO-8994( RO8994 )

Catalog No. M11239 CAS No. 1309684-94-3

A highly potent and selective, small-molecule p53-MDM2 inhibitor with HRFT IC50 of 5 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 43 In Stock
5MG 71 In Stock
10MG 116 In Stock
25MG 219 In Stock
50MG 345 In Stock
100MG 512 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    RO-8994
  • Note
    Research use only, not for human use.
  • Brief Description
    A highly potent and selective, small-molecule p53-MDM2 inhibitor with HRFT IC50 of 5 nM.
  • Description
    A highly potent and selective, small-molecule p53-MDM2 inhibitor with HRFT IC50 of 5 nM; shows marked improvement in both in vitro and in vivo pharmacological properties.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    RO8994
  • Pathway
    Apoptosis
  • Target
    MDM2-p53
  • Recptor
    Mdm2|P53
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1309684-94-3
  • Formula Weight
    613.5067
  • Molecular Formula
    C31H31Cl2FN4O4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 45 mg/mL
  • SMILES
    CC(C)(C)CC1C2(C(C(N1)C(=O)NC3=C(C=C(C=C3)C(=O)N)OC)C4=C(C(=CC=C4)Cl)F)C5=C(C=C(C=C5)Cl)NC2=O
  • Chemical Name
    Spiro[3H-indole-3,3'-pyrrolidine]-5'-carboxamide, N-[4-(aminocarbonyl)-2-methoxyphenyl]-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-1,2-dihydro-2-oxo-, (2'S,3R,4'S,5'R)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Zhang Z, et al. Bioorg Med Chem. 2014 Aug 1;22(15):4001-9. 2. Yu B, et al. Anticancer Agents Med Chem. 2016;16(10):1315-24.
molnova catalog
related products
  • APR-246

    APR-246 (PRIMA-1MET) is a methylated derivative of PRIMA-1 that restores mutant p53 activity.

  • UNC-2170

    UNC-2170 is a small molecule ligand for the methyl-lysine binding protein 53BP1 (p53-binding protein 1) with Kd of 22 uM against the 53BP1 tandem tudor domain.

  • CB-002

    A novel small molecule that restores p53 function in mutant p53-expressing colorectal cancer cells without toxicity to normal human fibroblasts.