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RO-2468
CAS No. 1360821-21-1
RO-2468( RO 2468 | RO2468 )
Catalog No. M11485 CAS No. 1360821-21-1
A potent, selective, and orally active p53-MDM2 antagonist with IC50 of 6 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameRO-2468
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective, and orally active p53-MDM2 antagonist with IC50 of 6 nM.
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DescriptionA potent, selective, and orally active p53-MDM2 antagonist with IC50 of 6 nM; exhibits substantial cellular antiproliferative potency/selectivity and comparse favorably to RO8994; displays tumor regression in tumor models at 10 mg/kg.
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In Vitro——
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In Vivo——
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SynonymsRO 2468 | RO2468
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PathwayApoptosis
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TargetMDM2-p53
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RecptorMDM2-p53
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Research Area——
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Indication——
Chemical Information
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CAS Number1360821-21-1
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Formula Weight614.499
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Molecular FormulaC30H30Cl2FN5O4
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C([C@H]1[C@H](C2=CC=CC(Cl)=C2F)[C@@]3(C4=C(NC3=O)C=C(Cl)N=C4)[C@H](CC(C)(C)C)N1)NC5=CC=C(C(N)=O)C=C5OC
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Chemical Name(2S,3R,4S,5R)-N-(4-carbamoyl-2-methoxyphenyl)-6'-chloro-4-(3-chloro-2-fluorophenyl)-2-neopentyl-2'-oxo-1',2'-dihydrospiro[pyrrolidine-3,3'-pyrrolo[3,2-c]pyridine]-5-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Zhang Z, et al. ACS Med Chem Lett. 2013 Dec 29;5(2):124-7.
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