NSC-319726( NSC319726 )

Catalog No. M15734 CAS No. 71555-25-4

NSC-319726 (NSC319726) is an allele-specific p53 mutant reactivator.

Purity : >98% (HPLC)

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Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

NSC-319726
Note

Research use only, not for human use.
Brief Description

NSC-319726 (NSC319726) is an allele-specific p53 mutant reactivator.
Description

NSC-319726 (NSC319726) is an allele-specific p53 mutant reactivator; restores WT structure and function to the p53(R175) mutant; kills p53(R172H) knockin mice with extensive apoptosis and inhibits xenograft tumor growth in a 175-allele-specific mutant p53-dependent manner.
In Vitro

——
In Vivo

——
Synonyms

NSC319726
Pathway

Apoptosis
Target

MDM2-p53
Recptor

p53(R175)
Research Area

Cancer
Indication

——

Chemical Information

CAS Number

71555-25-4
Formula Weight

234.3207
Molecular Formula

C11H14N4S
Purity

>98% (HPLC)
Solubility

DMSO: 27.5 mg/mL
SMILES

C/C(=N\NC(=S)N1CCC1)/C2=CC=CC=N2
Chemical Name

1-Azetidinecarbothioic acid, 2-[1-(2-pyridinyl)ethylidene]hydrazide

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Yu X, et al. Cancer Cell. 2012 May 15;21(5):614-25. 2. Yu X, et al. Oncotarget. 2014 Oct 15;5(19):8879-92. 3. Yu X, et al. Mol Pharmacol. 2017 Jun;91(6):567-575. 4.?Shimada K, et al. Cell Chem Biol. 2018 May 17;25(5):585-594.e7.

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