MDL-800

Research use only, not for human use.

MDL-800 (MDL800) is a first-in-class, selective, cellular active SIRT6 allosteric activator.

MDL-800 (MDL800) is a first-in-class, selective, cellular active SIRT6 allosteric activator, increases SIRT6 deacetylation activity with EC50 of 10.3 uM in RHKK-ac-AMC and FDL assays; dramatically enhanced SIRT6 deacetylation activity by more than 22-fold, displays no activity toward SIRT1, SIRT3, SIRT4, and HDAC1-11 at 50-100 uM, as well as >10-fold selectivity toward SIRT2, SIRT5, and SIRT7; activates SIRT6 through a surface allosteric site induces H3K9ac and H3K56ac deacetylation and represses proliferation of HCC cells (IC50=23.3 uM); inhibits xenograft tumor growth of HCC cells in immunocompromised mice by activating the deacetylase activity of SIRT6.

MDL800

Chromatin/Epigenetic

Sirtuin

Sirtuin

——

——

2275619-53-7

626.29

C21H16BrCl2FN2O6S2

>98% (HPLC)

——

O=C(OC)C1=CC(NS(=O)(C2=CC(Cl)=CC(Cl)=C2)=O)=CC=C1S(=O)(NC3=CC(Br)=C(F)C=C3C)=O

methyl 2-(N-(5-bromo-4-fluoro-2-methylphenyl)sulfamoyl)-5-((3,5-dichlorophenyl)sulfonamido)benzoate

(-20℃)

With Ice Pack

≥ 2 years