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RIPK1-IN-7
CAS No. 2300982-44-7
RIPK1-IN-7 ( —— )
Catalog No. M26416 CAS No. 2300982-44-7
RIPK1-IN-7 is a potent and selective inhibitor of RIPK1(Kd of 4 nM and an enzymatic IC50 of 11 nM),andexhibits excellent antimetastasis activity in the experimental B16 melanoma lung metastasis model.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 335 | Get Quote |
|
| 10MG | 500 | Get Quote |
|
| 25MG | 806 | Get Quote |
|
| 50MG | 1098 | Get Quote |
|
| 100MG | 1485 | Get Quote |
|
| 500MG | 2961 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameRIPK1-IN-7
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NoteResearch use only, not for human use.
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Brief DescriptionRIPK1-IN-7 is a potent and selective inhibitor of RIPK1(Kd of 4 nM and an enzymatic IC50 of 11 nM),andexhibits excellent antimetastasis activity in the experimental B16 melanoma lung metastasis model.
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DescriptionRIPK1-IN-7 is a potent and selective inhibitor of RIPK1(Kd of 4 nM and an enzymatic IC50 of 11 nM),andexhibits excellent antimetastasis activity in the experimental B16 melanoma lung metastasis model.(In Vitro):In the TSZ-induced HT29 cell necroptosis model, RIPK1-IN-7 shows potent cell protection effect (EC50 of 2nM). RIPK1-IN-7 displays considerable activity against several other kinases(Flt4, TrkA, TrkB, TrkC, Axl, HRI, Mer, and MAP4K5 with IC50s of 20, 26, 8, 7, 35, 26, 29, and 27 nM, respectively).
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Synonyms——
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PathwayApoptosis
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TargetRIP kinase
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RecptorAntifungal
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Research Area——
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Indication——
Chemical Information
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CAS Number2300982-44-7
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Formula Weight481.5
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Molecular FormulaC25H22F3N5O2
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Purity>98% (HPLC)
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Solubility——
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SMILESCCn1cc(-c2ccc3N(CCc3c2)C(=O)Cc2cccc(OC(F)(F)F)c2)c2c(N)ncnc12
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Andrew Redington. Methods relating to the use of remote ischemic conditioning. US 20160038737 A1.
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