RIPK2-IN-2( RIPK2-IN-2 | RIPK2 IN 2 | RIPK2IN2 | RIPK2 inhibitor-2 | RIPK2 inhibitor 2 )

Catalog No. M12259 CAS No. 1581270-11-2

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

RIPK2-IN-2
Note

Research use only, not for human use.
Brief Description

A potent, selective receptor interacting protein-2 (RIP2) kinase inhibitor.
Description

A potent, selective receptor interacting protein-2 (RIP2) kinase inhibitor.
In Vitro

RIP2 kinase inhibitor 2 is a novel prodrug of a quinazolyl amine that inhibits RIP2 kinase. Receptor interacting protein-2 (RIP2) kinase is a TKL family serine/threonine protein kinase involved in innate immune signaling. Following activation, RIP2 kinase associates with NODI or NOD2 and appears to function principally as a molecular scaffold to bring together other kinases (TAK1, ΙΚΚα/β/γ) involved in NF-κΒ and mitogen-activated protein kinase activation.
In Vivo

——
Synonyms

RIPK2-IN-2 | RIPK2 IN 2 | RIPK2IN2 | RIPK2 inhibitor-2 | RIPK2 inhibitor 2
Pathway

Apoptosis
Target

RIP kinase
Recptor

RIP kinase
Research Area

Cancer
Indication

——

CAS Number

1581270-11-2
Formula Weight

432.5364
Molecular Formula

C21H28N4O4S
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

COCCOC1=C(S(=O)(C(C)(C)C)=O)C=C2C(NC3=NNC(C)=C3C)=CC=NC2=C1
Chemical Name

4-Quinolinamine, 6-[(1,1-dimethylethyl)sulfonyl]-N-(4,5-dimethyl-1H-pyrazol-3-yl)-7-(2-methoxyethoxy)-

1. Linda N. Casillas, et al. Amino-quinolines as kinase inhibitors. PCT Int. Appl. (2014), WO 2014043437 A1 20140320.

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