RI-1( RI-1 | RI1 | RI 1 )

Catalog No. M14422 CAS No. 415713-60-9

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

RI-1
Note

Research use only, not for human use.
Brief Description

RI-1 is a RAD51 inhibitor with IC50 ranging from 5 to 30μM.
Description

RI-1 is a RAD51 inhibitor with IC50 ranging from 5 to 30μM.
In Vitro

RI-1 (1-50 μM; 24 h) specifically inhibits homologous recombination (HR) in U2OS cells and stimulates single-strand annealing (SSA) in HEK293 cells.?RI-1 (5-20 μM; 30 min) inhibits HsRAD51 in a concentration-dependent manner.RI-1 (20 μM; 8 h) disrupts the formation of RAD51 foci after DNA damage in immortalized human fibroblasts.?RI-1 (15-25 μM; 24 h) sensitizes human cancer cells (HeLa, MCF-7 and U2OS) to cross-linking chemotherapy.
In Vivo

RI-1 (50 mg/kg; i.p. every 3 d for 30 d) significantly reduces triple negative breast cancer (TNBC) tumor growth in mice. Animal Model:Female BALB/c nude mice (6 weeks) bearing TNBC tumorDosage:50 mg/kg Administration:I.p. every 3 days for 30 days Result:Resulted in significant inhibition of tumor growth.
Synonyms

RI-1 | RI1 | RI 1
Pathway

Cell Cycle/DNA Damage
Target

DNA/RNA Synthesis
Recptor

RAD51
Research Area

Cancer
Indication

——

CAS Number

415713-60-9
Formula Weight

361.61
Molecular Formula

C14H11Cl3N2O3
Purity

>98% (HPLC)
Solubility

DMSO: 50 mg/mL (138.27 mM)
SMILES

ClC1=C(N2CCOCC2)C(=O)N(C1=O)C1=CC(Cl)=C(Cl)C=C1
Chemical Name

3-chloro-1-(3,4-dichlorophenyl)-4-(4-morpholinyl)-1H-pyrrole-2,5-dione

1. Budke B, et al. Nucleic Acids Res. 2012 Aug;40(15):7347-57.

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