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RG7834

CAS No. 2072057-17-9

RG7834( RO 7020322 )

Catalog No. M23930 CAS No. 2072057-17-9

RG7834 is a highly selective and orally bioavailable inhibitor of HBV(HBsAg and HBeAg and HBV DNA with IC50s of 2.8, 2.6, and 3.2 nM, respectively, in dHepaRG Cells).

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    RG7834
  • Note
    Research use only, not for human use.
  • Brief Description
    RG7834 is a highly selective and orally bioavailable inhibitor of HBV(HBsAg and HBeAg and HBV DNA with IC50s of 2.8, 2.6, and 3.2 nM, respectively, in dHepaRG Cells).
  • Description
    RG7834 is a highly selective and orally bioavailable inhibitor of HBV(HBsAg and HBeAg and HBV DNA with IC50s of 2.8, 2.6, and 3.2 nM, respectively, in dHepaRG Cells).
  • In Vitro
    RG7834 ((S)-(+)-64) is a highly selective and orally bioavailable HBV inhibitor, potently inhibits HBV antigens (both HBsAg and HBeAg) and HBV DNA, with IC50s of 2.8, 2.6, and 3.2 nM, respectively, in dHepaRG Cells.RG7834 has no activity against CYP3A4, CYP2D6, CYP2C9 (IC50s >50 μM) or hERG channel.
  • In Vivo
    RG7834 (4 mg/kg, twice daily for 21 days) shows anti-HBV efficacy in HBV-infected human liver chimeric uPA-SCID mice.RG7834 (2, 14.5 mg/kg, p.o.) exhibits good oral bioavail ability, with a half-life of 4.9 h in mice. Animal Model:HBV-infected human liver chimeric uPA-SCID mice Dosage:4 mg/kg Administration:Twice daily for 21 days Result:Reduced both HBsAg and HBeAg, also decreased serum HBV DNA by 0.6 log10 in mice.
  • Synonyms
    RO 7020322
  • Pathway
    Microbiology/Virology
  • Target
    HBV
  • Recptor
    HBeAg|HBsAg|HBV DNA
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2072057-17-9
  • Formula Weight
    401.45
  • Molecular Formula
    C22H27NO6
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:125 mg/mL (311.37 mM; Need ultrasonic)
  • SMILES
    CC(C)[C@@H]1CC2=CC(=C(C=C2C3=CC(=O)C(=CN13)C(=O)O)OC)OCCCOC
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Han X, et al. Discovery of RG7834: The First-in-Class Selective and Orally Available Small Molecule Hepatitis B Virus Expression Inhibitor with Novel Mechanism of Action. J Med Chem. 2018 Oct 4.
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