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RG7713

CAS No. 920022-47-5

RG7713( RO-5028442 | RG-7713 )

Catalog No. M16602 CAS No. 920022-47-5

RG7713 (RO5028442, RG-7713) is a potent, highly selective, brain-penetrant vasopressin 1a (hV1a receptor) antagonist with Ki of 1 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    RG7713
  • Note
    Research use only, not for human use.
  • Brief Description
    RG7713 (RO5028442, RG-7713) is a potent, highly selective, brain-penetrant vasopressin 1a (hV1a receptor) antagonist with Ki of 1 nM.
  • Description
    RG7713 (RO5028442, RG-7713) is a potent, highly selective, brain-penetrant vasopressin 1a (hV1a receptor) antagonist with Ki of 1 nM, shows no activiity on hV2 receptor (Ki>30 uM); displays moderate mouse affinity and excellent selectivity versus hV2 and hOT receptors.Other Indication Phase 1 Clinical(In Vitro):RG7713 (RO5028442) (compound 8) has excellent binding in and functional affinity for hV1a, moderate mouse affinity, and excellent selectivity versus human V2 (hV2) and human oxytocin (hOT) receptors. RG7713 (RO5028442) shows high solubility. RG7713 (RO5028442) is found to be highly selective against a panel of 89 targets. Finally, RG7713 (RO5028442) is identified as a suitable compound for clinical studies.
  • In Vitro
    RG7713 (RO5028442) (compound 8) has excellent binding in and functional affinity for hV1a, moderate mouse affinity, and excellent selectivity versus human V2 (hV2) and human oxytocin (hOT) receptors. RG7713 (RO5028442) shows high solubility. RG7713 (RO5028442) is found to be highly selective against a panel of 89 targets. Finally, RG7713 (RO5028442) is identified as a suitable compound for clinical studies.
  • In Vivo
    ——
  • Synonyms
    RO-5028442 | RG-7713
  • Pathway
    GPCR/G Protein
  • Target
    Vasopressin Receptor
  • Recptor
    hV1areceptor|mV1areceptor
  • Research Area
    Other Indications
  • Indication
    Other Disease

Chemical Information

  • CAS Number
    920022-47-5
  • Formula Weight
    437.97
  • Molecular Formula
    C25H28ClN3O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 10 mM （ < 1 mg/ml refers to the product slightly soluble or insoluble )
  • SMILES
    O=C(C1=CN(CCN(C)C)C2=C1C=CC(Cl)=C2)N3CCC4(CC3)OCC5=C4C=CC=C5
  • Chemical Name
    (6-Chloro-1-(2-(dimethylamino)ethyl)indol-3-yl)-spiro(1H-isobenzofuran-3,4'-piperidine)-1'-yl-methanone

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Ratni H, et al. J Med Chem. 2015 Mar 12;58(5):2275-89. 2. Umbricht D, et al. Neuropsychopharmacology. 2017 Aug;42(9):1914-1923.
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  • RG7713

    RG7713 (RO5028442, RG-7713) is a potent, highly selective, brain-penetrant vasopressin 1a (hV1a receptor) antagonist with Ki of 1 nM.

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