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QCA276
CAS No. 2126819-40-5
QCA276 ( QCA 276;QCA-276 )
Catalog No. M13384 CAS No. 2126819-40-5
QCA276 is a novel potent BET proteins inhibitor with IC50/Ki of 10/.3 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameQCA276
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NoteResearch use only, not for human use.
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Brief DescriptionQCA276 is a novel potent BET proteins inhibitor with IC50/Ki of 10/.3 nM.
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DescriptionQCA276 is a novel potent BET proteins inhibitor with IC50/Ki of 10/.3 nM, QCA276 is the BET ligand for PROTAC QCA570; effectively inhibits human BRD2, BRD3, and BRD4 BD1 and BD2 proteins with Ki of 2-20 nM.
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SynonymsQCA 276;QCA-276
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PathwayChromatin/Epigenetic
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TargetBromodomain
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RecptorBromodomain
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Research Area——
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Indication——
Chemical Information
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CAS Number2126819-40-5
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Formula Weight401.49
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Molecular FormulaC22H19N5OS
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Purity>98% (HPLC)
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Solubility——
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SMILESCC1=NN=C2N1C3=C(COC2)C(=C(S3)C#CC4=CN(N=C4)C)CC5=CC=CC=C5
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Chemical Name3-Benzyl-9-methyl-2-((1-methyl-1H-pyrazol-4-yl)ethynyl)-4H,6Hthieno[2,3-e][1,2,4]triazolo[3,4-c][1,4]oxazepine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Qin C, et al. J Med Chem. 2018 Jul 18. doi: 10.1021/acs.jmedchem.8b00506.
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