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IACS-9571
CAS No. 1800477-30-8
IACS-9571 ( IACS9571 )
Catalog No. M12738 CAS No. 1800477-30-8
IACS-9571 is a potent, selective dual TRIM24-BRPF1 bromodomain inhibitor with Kd of 31 and 14 nM, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 963 | Get Quote |
|
| 50MG | 1962 | Get Quote |
|
| 100MG | 2520 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameIACS-9571
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NoteResearch use only, not for human use.
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Brief DescriptionIACS-9571 is a potent, selective dual TRIM24-BRPF1 bromodomain inhibitor with Kd of 31 and 14 nM, respectively.
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DescriptionIACS-9571 is a potent, selective dual TRIM24-BRPF1 bromodomain inhibitor with Kd of 31 and 14 nM, respectively; displays 9- and 21-fold selectivity against BRPF2 and BRPF3, weaker affinities with BAZ2B (Kd= 400 nM) and the second domain of TAF1 (Kd=1,800 nM), and >7,700-fold selectivity versus BRD4 BD1 and BD2; demonstrates excellent cellular potency (EC50= 50 nM) and favorable pharmacokinetic properties; IACS-9571 is a chemical probe to investigate biological and pharmacological role of TRIM24 and/or BRPF1 bromodomain inhibition in vitro and in vivo.
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SynonymsIACS9571
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PathwayChromatin/Epigenetic
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TargetBromodomain
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RecptorBromodomain
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Research Area——
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Indication——
Chemical Information
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CAS Number1800477-30-8
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Formula Weight642.77
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Molecular FormulaC32H42N4O8S
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Purity>98% (HPLC)
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Solubility——
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SMILESCCCOC1=CC(=CC(=C1)OC2=CC3=C(C=C2NS(=O)(=O)C4=CC(=C(C=C4)OC)OC)N(C(=O)N3C)C)OCCCCN(C)C
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Chemical NameBenzenesulfonamide, N-[6-[3-[4-(dimethylamino)butoxy]-5-propoxyphenoxy]-2,3-dihydro-1,3-dimethyl-2-oxo-1H-benzimidazol-5-yl]-3,4-dimethoxy-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Gechijian LN, et al. Nat Chem Biol. 2018 Mar 5. doi: 10.1038/s41589-018-0010-y.
2. Palmer WS, et al. J Med Chem. 2016 Feb 25;59(4):1440-54.
3. Zhan Y, et al. Epigenetics Chromatin. 2015 Sep 21;8:37.
4. Appikonda S, et al. J Biol Chem. 2018 Mar 9. pii: jbc.RA118.002233.
2. Palmer WS, et al. J Med Chem. 2016 Feb 25;59(4):1440-54.
3. Zhan Y, et al. Epigenetics Chromatin. 2015 Sep 21;8:37.
4. Appikonda S, et al. J Biol Chem. 2018 Mar 9. pii: jbc.RA118.002233.
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