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LP99
CAS No. 1808951-93-0
LP99 ( LP 99 )
Catalog No. M12771 CAS No. 1808951-93-0
LP99 is the first potent and selective BRD7/9 bromodomain inhibitor with Kd of 99 nM for BRD9; inhibits IL‐6 secretion from THP‐1 cells in a dose‐dependent manner.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 132 | Get Quote |
|
| 10MG | 222 | Get Quote |
|
| 25MG | 483 | Get Quote |
|
| 50MG | 698 | Get Quote |
|
| 100MG | 972 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameLP99
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NoteResearch use only, not for human use.
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Brief DescriptionLP99 is the first potent and selective BRD7/9 bromodomain inhibitor with Kd of 99 nM for BRD9; inhibits IL‐6 secretion from THP‐1 cells in a dose‐dependent manner.
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DescriptionLP99 is the first potent and selective BRD7/9 bromodomain inhibitor with Kd of 99 nM for BRD9; inhibits IL‐6 secretion from THP‐1 cells in a dose‐dependent manner; decreases BRET for both BRD7 and BRD9 in both the H3.3 and H4 systems in a dose‐dependent manner, with cellular IC50 values in the low micromolar range for both histones.
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SynonymsLP 99
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PathwayChromatin/Epigenetic
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TargetBromodomain
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RecptorBromodomain
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Research Area——
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Indication——
Chemical Information
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CAS Number1808951-93-0
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Formula Weight516.05
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Molecular FormulaC26H30ClN3O4S
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(CC[C@H](NS(CC(C)C)(=O)=O)[C@H]1C2=CC=C(Cl)C=C2)N1C3=CC=C4C(N(C)C(C=C4C)=O)=C3
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Chemical NameN-[(2R,3S)-2-(4-chlorophenyl)-1-(1,2-dihydro-1,4-dimethyl-2-oxo-7-quinolinyl)-6-oxo-3-piperidinyl]-2-methyl-1-propanesulfonamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Clark PG, et al. Angew Chem Weinheim Bergstr Ger. 2015 May 18;127(21):6315-6319.
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