LP99 ( LP 99 )

Catalog No. M12771 CAS No. 1808951-93-0

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

LP99
Note

Research use only, not for human use.
Brief Description

LP99 is the first potent and selective BRD7/9 bromodomain inhibitor with Kd of 99 nM for BRD9; inhibits IL‐6 secretion from THP‐1 cells in a dose‐dependent manner.
Description

LP99 is the first potent and selective BRD7/9 bromodomain inhibitor with Kd of 99 nM for BRD9; inhibits IL‐6 secretion from THP‐1 cells in a dose‐dependent manner; decreases BRET for both BRD7 and BRD9 in both the H3.3 and H4 systems in a dose‐dependent manner, with cellular IC50 values in the low micromolar range for both histones.
Synonyms

LP 99
Pathway

Chromatin/Epigenetic
Target

Bromodomain
Recptor

Bromodomain
Research Area

——
Indication

——

CAS Number

1808951-93-0
Formula Weight

516.05
Molecular Formula

C26H30ClN3O4S
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(CC[C@H](NS(CC(C)C)(=O)=O)[C@H]1C2=CC=C(Cl)C=C2)N1C3=CC=C4C(N(C)C(C=C4C)=O)=C3
Chemical Name

N-[(2R,3S)-2-(4-chlorophenyl)-1-(1,2-dihydro-1,4-dimethyl-2-oxo-7-quinolinyl)-6-oxo-3-piperidinyl]-2-methyl-1-propanesulfonamide

1. Clark PG, et al. Angew Chem Weinheim Bergstr Ger. 2015 May 18;127(21):6315-6319.

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