QC-6352 ( QC6352 )

Catalog No. M12860 CAS No. 1851373-36-8

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

QC-6352
Note

Research use only, not for human use.
Brief Description

QC-6352 is a potent and selective KDM4 family inhibitor.
Description

QC-6352 is a potent and selective KDM4 family inhibitor with IC50 of 104, 56, 35, and 104 nM for KDM4A, KDM4B, KDM4C, and KDM4D, respectively; displays high selectivity over other KDM family members, with the exception of KDM5B (IC50=750 nM); shows a promising cellular potency (KYSE-150 EC50=3.5 nM, H3K36 MOA=1.5 nM); has excellent physical properties and drug-like characteristics, exhibits favorable in vivo efficacy in a breast cancer PDX model and reduces the tumor initiating cell populations which are associated with resistance to chemotherapy treatments.
Synonyms

QC6352
Pathway

Chromatin/Epigenetic
Target

Histone Demethylase
Recptor

Histone Demethylase
Research Area

——
Indication

——

CAS Number

1851373-36-8
Formula Weight

387.48
Molecular Formula

C24H25N3O2
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 25 mg/mL 64.52 mM
SMILES

O=C(O)C1=CC=NC=C1NC[C@@H]2CCCC3=C2C=CC(N(C)C4=CC=CC=C4)=C3
Chemical Name

(R)-3-(((6-(methyl(phenyl)amino)-1,2,3,4-tetrahydronaphthalen-1-yl)methyl)amino)isonicotinic acid

1. Chen YK, et al. ACS Med Chem Lett. 2017 Jul 27;8(8):869-874.

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