CBB3001( CBB-3001 | CBB 3001 )

Catalog No. M12479 CAS No. 1639358-50-1

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Datasheet

HNMR

HPLC

MSDS

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Product Name

CBB3001
Note

Research use only, not for human use.
Brief Description

CBB3001 (CBB-3001) is a novel potent, selective histone demethylase LSD1 inhibitor with IC50 of 21.25 uM.
Description

CBB3001 (CBB-3001) is a novel potent, selective histone demethylase LSD1 inhibitor with IC50 of 21.25 uM; potently inhibits LSD1 activity both in vitro and in vivo; CBB3001 also selectively inhibits the growth of human ovarian teratocarcinoma PA-1 and mouse embryonic carcinoma F9 cells, caused the downregulation of pluripotent stem cell proteins SOX2 and OCT4, does not have significant inhibition on the growth of human colorectal carcinoma HCT116 cells or mouse fibroblast NIH3T3 cells that do not express these stem cell proteins.
In Vitro

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In Vivo

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Synonyms

CBB-3001 | CBB 3001
Pathway

Chromatin/Epigenetic
Target

Histone Demethylase
Recptor

Histone Demethylase
Research Area

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Indication

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CAS Number

1639358-50-1
Formula Weight

349.427
Molecular Formula

C19H27NO5
Purity

>98% (HPLC)
Solubility

——
SMILES

CC(C)(C)OC(=O)NC1CC1C2=CC=C(C=C2)OC(=O)OC(C)(C)C
Chemical Name

tert-butyl 2-(4-(tert-butoxycarbonyloxy)phenyl)cyclopropylcarbamate

1. Hoang N, et al. Bioorg Med Chem. 2018 May 1;26(8):1523-1537.

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