JNJ-64619178( —— )

Catalog No. M23934 CAS No. 2086772-26-9

JNJ-64619178 is a selective, orally active, and pseudo-irreversible inhibitor of protein arginine methyltransferase 5 (IC50: 0.14 nM).

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	182	In Stock
5MG	170	In Stock
10MG	275	In Stock
25MG	567	In Stock
50MG	923	In Stock
100MG	1624	In Stock
200MG	Get Quote	In Stock
500MG	Get Quote	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

JNJ-64619178
Note

Research use only, not for human use.
Brief Description

JNJ-64619178 is a selective, orally active, and pseudo-irreversible inhibitor of protein arginine methyltransferase 5 (IC50: 0.14 nM).
Description

JNJ-64619178 is a selective, orally active, and pseudo-irreversible inhibitor of protein arginine methyltransferase 5 (IC50: 0.14 nM). It has effective activity In lung cancer.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Chromatin/Epigenetic
Target

Histone Demethylase
Recptor

PRMT5
Research Area

——
Indication

——

Chemical Information

CAS Number

2086772-26-9
Formula Weight

483.36
Molecular Formula

C22H23BrN6O2
Purity

>98% (HPLC)
Solubility

DMSO: 120 mg/mL (248.26 mM; Need ultrasonic)
SMILES

Nc1c(ccn2[C@H](C[C@H](CCc3ccc(cc(c(N)n4)Br)c4c3)[C@H]3O)[C@@H]3O)c2ncn1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Tongfei Wu, et al. Abstract 4859: JNJ-64619178, a selective and pseudo-irreversible PRMT5 inhibitor with potent in vitro and in vivo activity, demonstrated in several lung cancer models.

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