Propylthiouracil

Research use only, not for human use.

Propylthiouracil is a Thyroid Hormone Synthesis Inhibitor.

Propylthiouracil is a Thyroid Hormone Synthesis Inhibitor. A thiourea antithyroid agent. Propythiouracil inhibits the synthesis of thyroxine and inhibits the peripheral conversion of throxine to tri-iodothyronine. It is used in the treatment of hyperthyroidism.

Cell Viability Assay Cell Line:U-937 cells Concentration:5.5 μg/mL, 11 μg/mL, 110 μg/mL, 220 μg/mL, 330 μg/mL Incubation Time:24 hours Result:Induced cytotoxicity in a dose-dependent manner.

Animal Model:Adult C57BL/6J and wild-derived WSB/EiJ male mice (8-weeks old)Dosage:1.5 g/kg diet Administration:Iodine-deficient diet; for 7 weeks Result:Induced hypothyroidism in adult C57BL/6J and wild-derived WSB/EiJ male mice.

NSC 6498 | NSC 70461 | 6-n-Propylthiouracil | PTU

Endocrinology/Hormones

THR

Thyroid peripheral conversion

Endocrinology

——

51-52-5

170.24

C7H10N2OS

>98% (HPLC)

Ethanol: 19 mg/mL (111.61 mM); DMSO: 34 mg/mL (199.72 mM)

CCCC1=CC(=O)NC(=S)N1

6-(2,2,3,3,3-pentadeuteriopropyl)-2-sulfanylidene-1H-pyrimidin-4-one

(-20℃)

With Ice Pack

≥ 2 years