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Propylthiouracil

CAS No. 51-52-5

Propylthiouracil( NSC 6498 | NSC 70461 | 6-n-Propylthiouracil | PTU )

Catalog No. M14789 CAS No. 51-52-5

Propylthiouracil is a Thyroid Hormone Synthesis Inhibitor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Propylthiouracil
  • Note
    Research use only, not for human use.
  • Brief Description
    Propylthiouracil is a Thyroid Hormone Synthesis Inhibitor.
  • Description
    Propylthiouracil is a Thyroid Hormone Synthesis Inhibitor. A thiourea antithyroid agent. Propythiouracil inhibits the synthesis of thyroxine and inhibits the peripheral conversion of throxine to tri-iodothyronine. It is used in the treatment of hyperthyroidism.
  • In Vitro
    Cell Viability Assay Cell Line:U-937 cells Concentration:5.5 μg/mL, 11 μg/mL, 110 μg/mL, 220 μg/mL, 330 μg/mL Incubation Time:24 hours Result:Induced cytotoxicity in a dose-dependent manner.
  • In Vivo
    Animal Model:Adult C57BL/6J and wild-derived WSB/EiJ male mice (8-weeks old)Dosage:1.5 g/kg diet Administration:Iodine-deficient diet; for 7 weeks Result:Induced hypothyroidism in adult C57BL/6J and wild-derived WSB/EiJ male mice.
  • Synonyms
    NSC 6498 | NSC 70461 | 6-n-Propylthiouracil | PTU
  • Pathway
    Endocrinology/Hormones
  • Target
    THR
  • Recptor
    Thyroid peripheral conversion
  • Research Area
    Endocrinology
  • Indication
    ——

Chemical Information

  • CAS Number
    51-52-5
  • Formula Weight
    170.24
  • Molecular Formula
    C7H10N2OS
  • Purity
    >98% (HPLC)
  • Solubility
    Ethanol: 19 mg/mL (111.61 mM); DMSO: 34 mg/mL (199.72 mM)
  • SMILES
    CCCC1=CC(=O)NC(=S)N1
  • Chemical Name
    6-(2,2,3,3,3-pentadeuteriopropyl)-2-sulfanylidene-1H-pyrimidin-4-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Sugawara M, et al. Thyroid. 1999 May;9(5):513-8.
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