CO23

Research use only, not for human use.

CO23 is a blood-brain barrier penetrant and selective TRα agonist and can be used in studies about the regulation of growth and development.

CO23 is a selective thyroid hormone receptor (TR) α agonist and used for growth and development regulation. CO23 was able to be transported through the blood-brain barrier.

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CO23 (ip; 0.04-5.0 nmol/g) has ≈50% cholesterol reduction with 0.8 nmol/g dose and higher doses are equally effective. CO23 has no effect at the lowest dose of 0.04 nmol/g and increases Dio1 mRNA 5-, 10-, and 15-fold at the doses of 0.8, 2.5, and 5 nmol/g, respectively.Animal Model:Hypothyroid Wistar rats Dosage:0.04, 0.8, 2.5, and 5.0 nmol/g Administration:Ip Result:Had ≈50% cholesterol reduction with 0.8 nmol/g dose and higher doses were equally effective.

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Endocrinology/Hormones

THR

Thyroid hormone receptor(THR)

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1370363-74-8

592.17

C19H18I2N2O4

>98% (HPLC)

In Vitro:?DMSO : 250 mg/mL (422.18 mM; Ultrasonic )

CC(C)c1cc(Oc2c(I)cc(CC3NC(=O)NC3=O)cc2I)ccc1O

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(-20℃)

With Ice Pack

≥ 2 years