CO23

CAS No. 1370363-74-8

CO23( —— )

Catalog No. M32851 CAS No. 1370363-74-8

CO23 is a blood-brain barrier penetrant and selective TRα agonist and can be used in studies about the regulation of growth and development.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 354 Get Quote
5MG 550 Get Quote
10MG 825 Get Quote
25MG 1316 Get Quote
50MG 1776 Get Quote
100MG 2331 Get Quote
500MG Get Quote Get Quote
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Biological Information

  • Product Name
    CO23
  • Note
    Research use only, not for human use.
  • Brief Description
    CO23 is a blood-brain barrier penetrant and selective TRα agonist and can be used in studies about the regulation of growth and development.
  • Description
    CO23 is a selective thyroid hormone receptor (TR) α agonist and used for growth and development regulation. CO23 was able to be transported through the blood-brain barrier.
  • In Vitro
    ——
  • In Vivo
    CO23 (ip; 0.04-5.0 nmol/g) has ≈50% cholesterol reduction with 0.8 nmol/g dose and higher doses are equally effective. CO23 has no effect at the lowest dose of 0.04 nmol/g and increases Dio1 mRNA 5-, 10-, and 15-fold at the doses of 0.8, 2.5, and 5 nmol/g, respectively.Animal Model:Hypothyroid Wistar rats Dosage:0.04, 0.8, 2.5, and 5.0 nmol/g Administration:Ip Result:Had ≈50% cholesterol reduction with 0.8 nmol/g dose and higher doses were equally effective.
  • Synonyms
    ——
  • Pathway
    Endocrinology/Hormones
  • Target
    THR
  • Recptor
    Thyroid hormone receptor(THR)
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1370363-74-8
  • Formula Weight
    592.17
  • Molecular Formula
    C19H18I2N2O4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 250 mg/mL (422.18 mM; Ultrasonic )
  • SMILES
    CC(C)c1cc(Oc2c(I)cc(CC3NC(=O)NC3=O)cc2I)ccc1O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Grijota-Martínez C, et al. In vivo activity of the thyroid hormone receptor beta- and α-selective agonists GC-24 and CO23on rat liver, heart, and brain. Endocrinology. 2011 Mar;152(3):1136-42.?
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