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CO23
CAS No. 1370363-74-8
CO23( —— )
Catalog No. M32851 CAS No. 1370363-74-8
CO23 is a blood-brain barrier penetrant and selective TRα agonist and can be used in studies about the regulation of growth and development.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 354 | Get Quote |
|
| 5MG | 550 | Get Quote |
|
| 10MG | 825 | Get Quote |
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| 25MG | 1316 | Get Quote |
|
| 50MG | 1776 | Get Quote |
|
| 100MG | 2331 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameCO23
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NoteResearch use only, not for human use.
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Brief DescriptionCO23 is a blood-brain barrier penetrant and selective TRα agonist and can be used in studies about the regulation of growth and development.
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DescriptionCO23 is a selective thyroid hormone receptor (TR) α agonist and used for growth and development regulation. CO23 was able to be transported through the blood-brain barrier.
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In Vitro——
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In VivoCO23 (ip; 0.04-5.0 nmol/g) has ≈50% cholesterol reduction with 0.8 nmol/g dose and higher doses are equally effective. CO23 has no effect at the lowest dose of 0.04 nmol/g and increases Dio1 mRNA 5-, 10-, and 15-fold at the doses of 0.8, 2.5, and 5 nmol/g, respectively.Animal Model:Hypothyroid Wistar rats Dosage:0.04, 0.8, 2.5, and 5.0 nmol/g Administration:Ip Result:Had ≈50% cholesterol reduction with 0.8 nmol/g dose and higher doses were equally effective.
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Synonyms——
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PathwayEndocrinology/Hormones
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TargetTHR
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RecptorThyroid hormone receptor(THR)
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Research Area——
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Indication——
Chemical Information
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CAS Number1370363-74-8
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Formula Weight592.17
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Molecular FormulaC19H18I2N2O4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 250 mg/mL (422.18 mM; Ultrasonic )
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SMILESCC(C)c1cc(Oc2c(I)cc(CC3NC(=O)NC3=O)cc2I)ccc1O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Grijota-Martínez C, et al. In vivo activity of the thyroid hormone receptor beta- and α-selective agonists GC-24 and CO23on rat liver, heart, and brain. Endocrinology. 2011 Mar;152(3):1136-42.?
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