Pracinostat

CAS No. 929016-96-6

Pracinostat ( SB939;SB-939;SB 939 )

Catalog No. M16653 CAS No. 929016-96-6

Pracinostat (SB939) is a potent, orally active HDAC inhibitor that potently inhibits class I, II, and IV HDACsw with Ki of 15-100 nM, inhibits HDAC1 with IC50 of 77 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 56 In Stock
5MG 88 In Stock
10MG 160 In Stock
25MG 267 In Stock
50MG 404 In Stock
100MG 597 In Stock
500MG 1251 In Stock
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Biological Information

  • Product Name
    Pracinostat
  • Note
    Research use only, not for human use.
  • Brief Description
    Pracinostat (SB939) is a potent, orally active HDAC inhibitor that potently inhibits class I, II, and IV HDACsw with Ki of 15-100 nM, inhibits HDAC1 with IC50 of 77 nM.
  • Description
    Pracinostat (SB939) is a potent, orally active HDAC inhibitor that potently inhibits class I, II, and IV HDACsw with Ki of 15-100 nM, inhibits HDAC1 with IC50 of 77 nM; shows cellular potency against COLO 205 cells with IC50 of 0.56 uM; Pracinostat (SB939) is highly efficacious in in vivo tumor models (HCT-116, PC-3, A2780, MV4-11, Ramos), and has high and dose-proportional oral exposures and very good ADME, safety, and pharmaceutical properties; also is a potent inhibitor of the growth of Plasmodium falciparum asexual-stage parasites in vitro (IC50=100 to 200 nM), causing hyperacetylation of parasite histone and nonhistone proteins.Blood Cancer Phase 3 Clinical
  • Synonyms
    SB939;SB-939;SB 939
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    HDAC
  • Recptor
    HDAC1;HDAC10;HDAC11;HDAC2;HDAC3;HDAC4;HDAC5;HDAC6;HDAC7;HDAC8;HDAC9
  • Research Area
    Cancer
  • Indication
    Blood cancer

Chemical Information

  • CAS Number
    929016-96-6
  • Formula Weight
    358.48
  • Molecular Formula
    C20H30N4O2
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    O=C(NO)/C=C/C1=CC=C2N(CCN(CC)CC)C(CCCC)=NC2=C1
  • Chemical Name
    2-Propenamide, 3-[2-butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl]-N-hydroxy-, (2E)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Wang H, et al. J Med Chem. 2011 Jul 14;54(13):4694-720.
2. Novotny-Diermayr V, et al. Mol Cancer Ther. 2011 Jul;10(7):1207-17.
3. Sumanadasa SD, et al. Antimicrob Agents Chemother. 2012 Jul;56(7):3849-56.
4. Razak AR, et al. Br J Cancer. 2011 Mar 1;104(5):756-62.
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