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Pracinostat
CAS No. 929016-96-6
Pracinostat ( SB939;SB-939;SB 939 )
Catalog No. M16653 CAS No. 929016-96-6
Pracinostat (SB939) is a potent, orally active HDAC inhibitor that potently inhibits class I, II, and IV HDACsw with Ki of 15-100 nM, inhibits HDAC1 with IC50 of 77 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 56 | In Stock |
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| 5MG | 88 | In Stock |
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| 10MG | 160 | In Stock |
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| 25MG | 267 | In Stock |
|
| 50MG | 404 | In Stock |
|
| 100MG | 597 | In Stock |
|
| 500MG | 1251 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePracinostat
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NoteResearch use only, not for human use.
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Brief DescriptionPracinostat (SB939) is a potent, orally active HDAC inhibitor that potently inhibits class I, II, and IV HDACsw with Ki of 15-100 nM, inhibits HDAC1 with IC50 of 77 nM.
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DescriptionPracinostat (SB939) is a potent, orally active HDAC inhibitor that potently inhibits class I, II, and IV HDACsw with Ki of 15-100 nM, inhibits HDAC1 with IC50 of 77 nM; shows cellular potency against COLO 205 cells with IC50 of 0.56 uM; Pracinostat (SB939) is highly efficacious in in vivo tumor models (HCT-116, PC-3, A2780, MV4-11, Ramos), and has high and dose-proportional oral exposures and very good ADME, safety, and pharmaceutical properties; also is a potent inhibitor of the growth of Plasmodium falciparum asexual-stage parasites in vitro (IC50=100 to 200 nM), causing hyperacetylation of parasite histone and nonhistone proteins.Blood Cancer Phase 3 Clinical
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SynonymsSB939;SB-939;SB 939
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PathwayCell Cycle/DNA Damage
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TargetHDAC
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RecptorHDAC1;HDAC10;HDAC11;HDAC2;HDAC3;HDAC4;HDAC5;HDAC6;HDAC7;HDAC8;HDAC9
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Research AreaCancer
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IndicationBlood cancer
Chemical Information
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CAS Number929016-96-6
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Formula Weight358.48
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Molecular FormulaC20H30N4O2
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C(NO)/C=C/C1=CC=C2N(CCN(CC)CC)C(CCCC)=NC2=C1
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Chemical Name2-Propenamide, 3-[2-butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl]-N-hydroxy-, (2E)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Wang H, et al. J Med Chem. 2011 Jul 14;54(13):4694-720.
2. Novotny-Diermayr V, et al. Mol Cancer Ther. 2011 Jul;10(7):1207-17.
3. Sumanadasa SD, et al. Antimicrob Agents Chemother. 2012 Jul;56(7):3849-56.
4. Razak AR, et al. Br J Cancer. 2011 Mar 1;104(5):756-62.
2. Novotny-Diermayr V, et al. Mol Cancer Ther. 2011 Jul;10(7):1207-17.
3. Sumanadasa SD, et al. Antimicrob Agents Chemother. 2012 Jul;56(7):3849-56.
4. Razak AR, et al. Br J Cancer. 2011 Mar 1;104(5):756-62.
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