Piclamilast

Research use only, not for human use.

Piclamilast is a PDE4 inhibitor.

Piclamilast is a PDE4 inhibitor.(In Vitro):Piclamilast pre-treatment significantly inhibited the changes in 23 genes via mechanisms involving AP-1 activation and c-Jun phosphorylation at Ser63. The IC50s for Piclamilast was 16 nM and 2 nM in pig aorta and eosinophil soluble, respectively. Piclamilast exhibited IC50 values >100 μM, 40 μM, >100 μM, 14 μM for PDE1, PDE2, PDE3 and PDE5. Respectively.(In Vivo):Initial in vivo studies conducted in severe combined immunodeficiency mice transplanted with NB4 leukemia cells indicate that the enhancing effect of piclamilast on ATRA-induced myeloid maturation translates into a therapeutic benefit.

RP 73401; RPR 73401

Angiogenesis

PDE

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——

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144035-83-6

381.3

C18H18Cl2N2O3

>98% (HPLC)

——

COc1ccc(cc1OC1CCCC1)C(=O)Nc1c(Cl)cncc1Cl

——

(-20℃)

With Ice Pack

≥ 2 years