Phosphoserine

Research use only, not for human use.

The phosphoric acid ester of serine.

The phosphoric acid ester of serine.

O-Phospho-L-serine (l-SOP) weakly binds to mGluR1, and antagonizes the effects of l-glutamate. l-SOP activates the group III receptors (mGluR4, mGluR6, mGluR7, and mGluR8), but mGluR7 has much lower affinity for l-SOP than the other group III receptors and also displays lower efficacy for both ligands. O-Phospho-L-serine (l-SOP) generates enhanced intracellular calcium responses in mGluR4 transfected cells. l-SOP inhibits the l-glutamate mediated mGluR1 response, with a Ki of 1 mM; l-SOP displays a substantially more potent inhibition of mGluR2 activation, with a Ki of 1 μM, three orders-of-magnitude more potent than for mGluR1. l-SOP induces membrane potential changes in HEK/TRPC4 cells transfected with mGluR4 or mGluR6. l-SOP induces TRPC4β activation mediated by Gαi/o proteins. O-Phospho-L-serine (L-SOP) inhibits Müller glia proliferation, without affecting light-induced photoreceptor cell death. L-SOP disrupts Müller glia proliferation subsequent to or in parallel with the activation of ascl1a and stat3 expression in the light-damaged retina. L-SOP inhibits cone cell regeneration in the light-damaged retina.

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Dexfosfoserine | L-Serine-O-Phosphate | L-SOP

Neuroscience

Other Targets

Amino Acids and Derivatives| NMDA receptor

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407-41-0

185.07

C3H8NO6P

>98% (HPLC)

Water: 100 mM

C([C@@H](C(=O)O)N)OP(=O)(O)O

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(-20℃)

With Ice Pack

≥ 2 years