Panobinostat

CAS No. 404950-80-7

Panobinostat ( LBH-589;LBH589;NVP-LBH589 )

Catalog No. M14388 CAS No. 404950-80-7

A potent, broad-spectrum HDAC inhibitor with IC50 of 5-20 nM in cell-free assyas.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 29 In Stock
10MG 47 In Stock
25MG 72 In Stock
50MG 96 In Stock
100MG 132 In Stock
200MG 168 In Stock
500MG 345 In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Panobinostat
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, broad-spectrum HDAC inhibitor with IC50 of 5-20 nM in cell-free assyas.
  • Description
    A potent, broad-spectrum HDAC inhibitor with IC50 of 5-20 nM in cell-free assyas; induces cell-cycle arrest, apoptosis, and histone (H3K9 and H4K8) hyperacetylation, increases mRNA levels of proapoptosis, growth arrest, and DNA damage repair genes including FANCG, FOXO3A, GADD45A, GADD45B, and GADD45G; significantly slows tumor growth derived from Meso and NSCLC cells in vivo models.Blood Cancer Approved
  • Synonyms
    LBH-589;LBH589;NVP-LBH589
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    HDAC
  • Recptor
    HDAC(MOLT-4cells);HDAC(Rehcells)
  • Research Area
    Cancer
  • Indication
    Blood cancer

Chemical Information

  • CAS Number
    404950-80-7
  • Formula Weight
    349.43
  • Molecular Formula
    C21H23N3O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 57 mg/mL
  • SMILES
    O=C(NO)/C=C/C1=CC=C(CNCCC2=C(C)NC3=C2C=CC=C3)C=C1
  • Chemical Name
    2-Propenamide, N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-, (2E)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Crisanti MC, et al. Mol Cancer Ther. 2009 Aug;8(8):2221-31.
2. George P, et al. Blood. 2005 Feb 15;105(4):1768-76.
3. Scuto A, et al. Blood. 2008 May 15;111(10):5093-100.
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