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Panobinostat
CAS No. 404950-80-7
Panobinostat ( LBH-589;LBH589;NVP-LBH589 )
Catalog No. M14388 CAS No. 404950-80-7
A potent, broad-spectrum HDAC inhibitor with IC50 of 5-20 nM in cell-free assyas.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 29 | In Stock |
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| 10MG | 47 | In Stock |
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| 25MG | 72 | In Stock |
|
| 50MG | 96 | In Stock |
|
| 100MG | 132 | In Stock |
|
| 200MG | 168 | In Stock |
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| 500MG | 345 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePanobinostat
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, broad-spectrum HDAC inhibitor with IC50 of 5-20 nM in cell-free assyas.
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DescriptionA potent, broad-spectrum HDAC inhibitor with IC50 of 5-20 nM in cell-free assyas; induces cell-cycle arrest, apoptosis, and histone (H3K9 and H4K8) hyperacetylation, increases mRNA levels of proapoptosis, growth arrest, and DNA damage repair genes including FANCG, FOXO3A, GADD45A, GADD45B, and GADD45G; significantly slows tumor growth derived from Meso and NSCLC cells in vivo models.Blood Cancer Approved
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SynonymsLBH-589;LBH589;NVP-LBH589
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PathwayCell Cycle/DNA Damage
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TargetHDAC
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RecptorHDAC(MOLT-4cells);HDAC(Rehcells)
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Research AreaCancer
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IndicationBlood cancer
Chemical Information
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CAS Number404950-80-7
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Formula Weight349.43
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Molecular FormulaC21H23N3O2
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 57 mg/mL
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SMILESO=C(NO)/C=C/C1=CC=C(CNCCC2=C(C)NC3=C2C=CC=C3)C=C1
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Chemical Name2-Propenamide, N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-, (2E)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Crisanti MC, et al. Mol Cancer Ther. 2009 Aug;8(8):2221-31.
2. George P, et al. Blood. 2005 Feb 15;105(4):1768-76.
3. Scuto A, et al. Blood. 2008 May 15;111(10):5093-100.
2. George P, et al. Blood. 2005 Feb 15;105(4):1768-76.
3. Scuto A, et al. Blood. 2008 May 15;111(10):5093-100.
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