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PV-1019
CAS No. ——
PV-1019( NSC-744039 | NSC744039 | PV1019 )
Catalog No. M16921 CAS No. ——
A potent, ATP-competitive and highly selective Chk2 inhibitor with IC50 of 138 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NamePV-1019
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, ATP-competitive and highly selective Chk2 inhibitor with IC50 of 138 nM.
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DescriptionA potent, ATP-competitive and highly selective Chk2 inhibitor with IC50 of 138 nM; displays much reduced or no activity against a panel of 52 other cellular kinases, including Chk1; inhibits Chk2-mediated phosphorylation of Cdc25C (IC50=260 nM), and nd HDMX degradation in response to DNA damage; protects normal mouse thymocytes against ionizing radiation-induced apoptosis.
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In Vitro——
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In Vivo——
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SynonymsNSC-744039 | NSC744039 | PV1019
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PathwayAngiogenesis
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TargetChk
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RecptorChk
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Research Area——
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Indication——
Chemical Information
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CAS Number——
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Formula Weight379.38
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Molecular FormulaC18H17N7O3
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name7-nitro-1H-indole-2-carboxylic acid {4-[1-(guanidinohydrazone)-ethyl]-phenyl}-amide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Jobson AG, et al. J Pharmacol Exp Ther. 2009 Dec; 331(3):816-26.
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