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PKI-402
CAS No. 1173204-81-3
PKI-402 ( PKI 402;PKI402 )
Catalog No. M10583 CAS No. 1173204-81-3
A potent dual PI3K/mTOR inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 110 | In Stock |
|
| 10MG | 177 | In Stock |
|
| 25MG | 357 | In Stock |
|
| 50MG | 530 | In Stock |
|
| 100MG | 759 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePKI-402
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NoteResearch use only, not for human use.
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Brief DescriptionA potent dual PI3K/mTOR inhibitor.
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DescriptionA potent dual PI3K/mTOR inhibitor with IC50 of 1/7/16/14/1.7 nM for PI3Kα/β/γ/δ/mTOR respectively; shows excellent suppression of Akt T308 phosphorylation (IC50=5 nM), and excellent inhibition of cell proliferation in several human cancer cell lines; shows excellent in vivo efficacy in various human cancer xenografts, good physical properties and PK parameters.
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SynonymsPKI 402;PKI402
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PathwayPI3K/Akt/mTOR signaling
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TargetPI3K
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RecptorPI3K
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1173204-81-3
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Formula Weight570.65
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Molecular FormulaC29H34N10O3
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Purity>98% (HPLC)
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SolubilityDMSO: < 1 mg/mL
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SMILESO=C(NC1=CC=C(C(N2CCN(C)CC2)=O)C=C1)NC3=CC=C(C4=NC(N5CCOCC5)=C(N=NN6CC)C6=N4)C=C3
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Chemical NameUrea, N-[4-[3-ethyl-7-(4-morpholinyl)-3H-1,2,3-triazolo[4,5-d]pyrimidin-5-yl]phenyl]-N'-[4-[(4-methyl-1-piperazinyl)carbonyl]phenyl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Dehnhardt CM, et al. J Med Chem. 2010 Jan 28;53(2):798-810.
2. Mallon R, et al. Mol Cancer Ther. 2010 Apr;9(4):976-84.
2. Mallon R, et al. Mol Cancer Ther. 2010 Apr;9(4):976-84.
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