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Dactolisib

CAS No. 915019-65-7

Dactolisib ( NVP-BEZ235;BEZ-235 )

Catalog No. M16571 CAS No. 915019-65-7

A potent, dual ATP-competitive pan-class I PI3K and mTOR inhibitor for p110α/γ/δ/β and mTOR(p70S6K) with IC50 of 4 nM /5 nM /7 nM /75 nM /6 nM, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Dactolisib
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, dual ATP-competitive pan-class I PI3K and mTOR inhibitor for p110α/γ/δ/β and mTOR(p70S6K) with IC50 of 4 nM /5 nM /7 nM /75 nM /6 nM, respectively.
  • Description
    A potent, dual ATP-competitive pan-class I PI3K and mTOR inhibitor for p110α/γ/δ/β and mTOR(p70S6K) with IC50 of 4 nM /5 nM /7 nM /75 nM /6 nM, respectively; effectively and specifically blocks the dysfunctional activation of the PI3K pathway, inducing G(1) arrest; demonstrates antitumor activity in in vivo models of human cancer.Kidney Cancer Phase 2 Discontinued
  • Synonyms
    NVP-BEZ235;BEZ-235
  • Pathway
    PI3K/Akt/mTOR signaling
  • Target
    PI3K
  • Recptor
    ATR;mTOR(p70S6K);p110α;p110γ;p110δ;p110β
  • Research Area
    Cancer
  • Indication
    Kidney Cancer

Chemical Information

  • CAS Number
    915019-65-7
  • Formula Weight
    469.54
  • Molecular Formula
    C30H23N5O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 8.75 mg/mL
  • SMILES
    CC(C1=CC=C(N(C2=C3C=NC4=CC=C(C5=CC6=CC=CC=C6N=C5)C=C24)C(N3C)=O)C=C1)(C)C#N
  • Chemical Name
    Benzeneacetonitrile, 4-[2,3-dihydro-3-methyl-2-oxo-8-(3-quinolinyl)-1H-imidazo[4,5-c]quinolin-1-yl]-.alpha.,.alpha.-dimethyl-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Maira SM, et al. Mol Cancer Ther. 2008 Jul;7(7):1851-63.
2. Serra V, et al. Cancer Res. 2008 Oct 1;68(19):8022-30.
3. Schnell CR, et al. Cancer Res. 2008 Aug 15;68(16):6598-607.
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