β-catenin-IN-11a( —— )

Catalog No. M12944 CAS No. 1884472-26-7

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

β-catenin-IN-11a
Note

Research use only, not for human use.
Brief Description

β-catenin-IN-11a is a β-catenin/CD44/Nanog axis inhibitor, docks into the β-catenin allosteric site and interferes β-catenin/TCF-4 complex.
Description

β-catenin-IN-11a is a β-catenin/CD44/Nanog axis inhibitor, docks into the β-catenin allosteric site and interferes β-catenin/TCF-4 complex; blocks the cell cycle inhibitory effect of CD44 and induces cell accumulation of CD44 high cells in cycling phase in S, G2 and M phase, leads to inhibition of embryonic transcriptional factor Nanog but not Sox2 or Oct-4 in colon cancer cells.
In Vitro

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In Vivo

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Synonyms

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Pathway

Wnt/Notch/Hedgehog
Target

Beta-catenin
Recptor

Beta-catenin
Research Area

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Indication

——

CAS Number

1884472-26-7
Formula Weight

504.59
Molecular Formula

C31H28N4O3
Purity

>98% (HPLC)
Solubility

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SMILES

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Chemical Name

N'-(1-((benzyl(methyl)amino)methyl)-2-oxoindolin-3-ylidene)-2-(benzyloxy)benzohydrazide

1. Radwan AA, et al. Bioorg Med Chem Lett. 2016 Apr 1;26(7):1664-70.

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