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Home - Products - Chromatin/Epigenetic - HMTase - PJ-68

PJ-68

CAS No. 352544-59-3

PJ-68( PJ68 )

Catalog No. M14202 CAS No. 352544-59-3

PJ-68 is a potent, selective inhibitor of arginine methyltransferase PRMT5 with IC50 of 517 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    PJ-68
  • Note
    Research use only, not for human use.
  • Brief Description
    PJ-68 is a potent, selective inhibitor of arginine methyltransferase PRMT5 with IC50 of 517 nM.
  • Description
    PJ-68 is a potent, selective inhibitor of arginine methyltransferase PRMT5 with IC50 of 517 nM, shows no inhibitory activity against type I PRMT family members ( (PRMT1, 3, 4, 6, and 8); markedly decreases BCR-ABL mRNA levels in both CD34+CD38-cells and CD34+CD38+ cells, reduces survival and self-renewal capacity of CML CD34+ cells, increases p15INK4B and p27KIP1 but not p16INK4A and p57KIP2 expression; reduces growth of CML LSCs and prolongs survival of CML mice.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    PJ68
  • Pathway
    Chromatin/Epigenetic
  • Target
    HMTase
  • Recptor
    HMTase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    352544-59-3
  • Formula Weight
    354.497
  • Molecular Formula
    C25H26N2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    N-((9-ethyl-9H-carbazol-3-yl)methyl)-1,2,3,4-tetrahydronaphthalen-1-amine

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Jin Y, et al. J Clin Invest. 2016 Oct 3;126(10):3961-3980. 2. Kaushik S, et al. Leukemia. 2018 Feb;32(2):499-509.
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