PJ-68
CAS No. 352544-59-3
PJ-68 ( PJ68 )
Catalog No. M14202 CAS No. 352544-59-3
PJ-68 is a potent, selective inhibitor of arginine methyltransferase PRMT5 with IC50 of 517 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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100MG | Get Quote | Get Quote |
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Biological Information
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Product NamePJ-68
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NoteResearch use only, not for human use.
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Brief DescriptionPJ-68 is a potent, selective inhibitor of arginine methyltransferase PRMT5 with IC50 of 517 nM.
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DescriptionPJ-68 is a potent, selective inhibitor of arginine methyltransferase PRMT5 with IC50 of 517 nM, shows no inhibitory activity against type I PRMT family members ( (PRMT1, 3, 4, 6, and 8); markedly decreases BCR-ABL mRNA levels in both CD34+CD38-cells and CD34+CD38+ cells, reduces survival and self-renewal capacity of CML CD34+ cells, increases p15INK4B and p27KIP1 but not p16INK4A and p57KIP2 expression; reduces growth of CML LSCs and prolongs survival of CML mice.
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SynonymsPJ68
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PathwayChromatin/Epigenetic
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TargetHMTase
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RecptorHMTase
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Research Area——
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Indication——
Chemical Information
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CAS Number352544-59-3
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Formula Weight354.50
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Molecular FormulaC25H26N2
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical NameN-((9-ethyl-9H-carbazol-3-yl)methyl)-1,2,3,4-tetrahydronaphthalen-1-amine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Jin Y, et al. J Clin Invest. 2016 Oct 3;126(10):3961-3980.
2. Kaushik S, et al. Leukemia. 2018 Feb;32(2):499-509.
2. Kaushik S, et al. Leukemia. 2018 Feb;32(2):499-509.
molnova catalog
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