MI-2-2 ( MI-2-2; MI22; MI 2 2 )

Catalog No. M11965 CAS No. 1454920-20-7

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Datasheet

HNMR

HPLC

MSDS

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Product Name

MI-2-2
Note

Research use only, not for human use.
Brief Description

MI-2-2 is a potent inhibitor of the menin-MLL interaction that binds to menin with low nanomolar affinity (Kd=22 nM).
Description

MI-2-2 is a potent inhibitor of the menin-MLL interaction that binds to menin with low nanomolar affinity (Kd=22 nM); inhibits the interaction of menin with MLL-AF9 in HEK293 cells in a dose-dependent manner with 4-fold potentcy improvement over MI-2; suppresses growth of MLL-AF9–transformed BMCs; causes MV4:11 cells growth inhibition of with GI50 of 3 uM.
Synonyms

MI-2-2; MI22; MI 2 2
Pathway

Chromatin/Epigenetic
Target

HMTase
Recptor

HMTase
Research Area

——
Indication

——

CAS Number

1454920-20-7
Formula Weight

415.50
Molecular Formula

C17H20F3N5S2
Purity

>98% (HPLC)
Solubility

——
SMILES

FC(F)(F)CC1=CC2=C(N3CCN(C4=NCC(C)(C)S4)CC3)N=CN=C2S1
Chemical Name

4-(4-(5,5-Dimethyl-4,5-dihydrothiazol-2-yl)piperazin-1-yl)-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidine

1. Arkin MR, et al. Chem Biol. 2014 Sep 18;21(9):1102-14.
2. Shi A, et al. Blood. 2012 Nov 29;120(23):4461-9.

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