Cart
sales@molnova.com
PIK-90
CAS No. 677338-12-4
PIK-90 ( PIK90;PIK 90 )
Catalog No. M15589 CAS No. 677338-12-4
PIK-90 is a potent DNA-PK and PI3K inhibitor that inhibits p110α, p110γ and DNA-PK with IC50s of 11, 18 and 13 nM, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 35 | In Stock |
|
| 10MG | 42 | In Stock |
|
| 25MG | 77 | In Stock |
|
| 50MG | 132 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NamePIK-90
-
NoteResearch use only, not for human use.
-
Brief DescriptionPIK-90 is a potent DNA-PK and PI3K inhibitor that inhibits p110α, p110γ and DNA-PK with IC50s of 11, 18 and 13 nM, respectively.
-
DescriptionPIK-90 is a potent DNA-PK and PI3K inhibitor that inhibits p110α, p110γ and DNA-PK with IC50s of 11, 18 and 13 nM, respectively; inhibits phosphorylation of Akt and S6, blocks the antiapoptotic protein Survivin and driving cell death in malignant glioma the clinical CDK1/2 inhibitor cooperated with roscovitine.
-
SynonymsPIK90;PIK 90
-
PathwayPI3K/Akt/mTOR signaling
-
TargetPI3K
-
RecptorPI3Kα;PI3Kβ;PI3Kγ;PI3Kδ
-
Research AreaCancer
-
Indication——
Chemical Information
-
CAS Number677338-12-4
-
Formula Weight351.36
-
Molecular FormulaC18H17N5O3
-
Purity>98% (HPLC)
-
SolubilityDMSO: < 1 mg/mL
-
SMILESO=C(NC1=NC2=C(C=CC(OC)=C2OC)C3=NCCN13)C4=CN=CC=C4
-
Chemical Name3-Pyridinecarboxamide, N-(2,3-dihydro-7,8-dimethoxyimidazo[1,2-c]quinazolin-5-yl)-
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Fan QW, et al. Cancer Res. 2007 Sep 1;67(17):7960-5.
2. Niedermeier M, et al. Blood. 2009 May 28;113(22):5549-57.
3. Knight ZA, et al. Cell. 2006 May 19;125(4):733-47.
4. Cheng CK, et al. Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12722-7.
2. Niedermeier M, et al. Blood. 2009 May 28;113(22):5549-57.
3. Knight ZA, et al. Cell. 2006 May 19;125(4):733-47.
4. Cheng CK, et al. Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12722-7.
molnova catalog
related products
-
GDC-0980
GDC-0980 (Apitolisib, GNE 390, RG 7422) is a potent, selective, orally available class I PI3K/mTOR inhibitor with IC50 of 5 nM/27 nM/7 nM/14 nM for PI3Kα/β/δ/γ, inhibits mTOR inhibitor with Ki of 17 nM.
-
NIBR-17
NIBR-17 is a pan class I PI3K inhibitor. NIBR-17 inhibits PI3KKα, PI3KKβ, PI3KKγ, and PI3KKδ with IC50 of 1 nM, 9.2 nM, 9 nM, and 20 nM respectively.
-
AMG 511
A potent, efficacious, and orally available pan class I PI3K inhibitor.
