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Voxtalisib
CAS No. 934493-76-2
Voxtalisib ( XL765;SAR245409;SAR-245409;XL 765;XL-765 )
Catalog No. M16680 CAS No. 934493-76-2
A potent, highly selective ATP-competitive inhibitor of class I PI3Ks.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 41 | In Stock |
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| 5MG | 65 | In Stock |
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| 10MG | 113 | In Stock |
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| 25MG | 227 | In Stock |
|
| 50MG | 365 | In Stock |
|
| 100MG | 531 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameVoxtalisib
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, highly selective ATP-competitive inhibitor of class I PI3Ks.
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DescriptionA potent, highly selective ATP-competitive inhibitor of class I PI3Ks with IC50s of 39/110/43/9 nM for p110α/p110β/p110δ/p120γ; also inhibits mTORC1/mTORC2/DNA-PK (IC50=160/910/150 nM) and shows weak inhibitory activity toward VPS34 (IC50=9.1 uM); inhibits phosphorylation of AKT, p70S6K, and S6 phosphorylation in multiple tumor cell lines; orally bioactive in mouse xenograft models.Solid Tumors Phase 2 Clinical
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SynonymsXL765;SAR245409;SAR-245409;XL 765;XL-765
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PathwayPI3K/Akt/mTOR signaling
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TargetPI3K
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RecptorDNA-PK;PI3Kα;PI3Kβ;PI3Kγ;PI3Kδ
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Research AreaCancer
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IndicationSolid Tumors
Chemical Information
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CAS Number934493-76-2
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Formula Weight270.29
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Molecular FormulaC13H14N6O
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Purity>98% (HPLC)
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SolubilityDMSO: 16 mg/mL
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SMILESO=C1C(C2=CC=NN2)=CC3=C(C)N=C(N)N=C3N1CC
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Chemical NamePyrido[2,3-d]pyrimidin-7(8H)-one, 2-amino-8-ethyl-4-methyl-6-(1H-pyrazol-3-yl)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Yu P, et al. Mol Cancer Ther. 2014 May;13(5):1078-91.
2. Papadopoulos KP, et al. Clin Cancer Res. 2014 May 1;20(9):2445-56.
3. Thijssen R, et al. Leukemia. 2016 Feb;30(2):337-45.
2. Papadopoulos KP, et al. Clin Cancer Res. 2014 May 1;20(9):2445-56.
3. Thijssen R, et al. Leukemia. 2016 Feb;30(2):337-45.
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