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Voxtalisib

CAS No. 934493-76-2

Voxtalisib ( XL765;SAR245409;SAR-245409;XL 765;XL-765 )

Catalog No. M16680 CAS No. 934493-76-2

A potent, highly selective ATP-competitive inhibitor of class I PI3Ks.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 65 In Stock
10MG 113 In Stock
25MG 227 In Stock
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Biological Information

  • Product Name
    Voxtalisib
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, highly selective ATP-competitive inhibitor of class I PI3Ks.
  • Description
    A potent, highly selective ATP-competitive inhibitor of class I PI3Ks with IC50s of 39/110/43/9 nM for p110α/p110β/p110δ/p120γ; also inhibits mTORC1/mTORC2/DNA-PK (IC50=160/910/150 nM) and shows weak inhibitory activity toward VPS34 (IC50=9.1 uM); inhibits phosphorylation of AKT, p70S6K, and S6 phosphorylation in multiple tumor cell lines; orally bioactive in mouse xenograft models.Solid Tumors Phase 2 Clinical
  • Synonyms
    XL765;SAR245409;SAR-245409;XL 765;XL-765
  • Pathway
    PI3K/Akt/mTOR signaling
  • Target
    PI3K
  • Recptor
    DNA-PK;PI3Kα;PI3Kβ;PI3Kγ;PI3Kδ
  • Research Area
    Cancer
  • Indication
    Solid Tumors

Chemical Information

  • CAS Number
    934493-76-2
  • Formula Weight
    270.29
  • Molecular Formula
    C13H14N6O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 16 mg/mL
  • SMILES
    O=C1C(C2=CC=NN2)=CC3=C(C)N=C(N)N=C3N1CC
  • Chemical Name
    Pyrido[2,3-d]pyrimidin-7(8H)-one, 2-amino-8-ethyl-4-methyl-6-(1H-pyrazol-3-yl)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Yu P, et al. Mol Cancer Ther. 2014 May;13(5):1078-91.
2. Papadopoulos KP, et al. Clin Cancer Res. 2014 May 1;20(9):2445-56.
3. Thijssen R, et al. Leukemia. 2016 Feb;30(2):337-45.
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