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PI-103
CAS No. 371935-74-9
PI-103 ( PI 103;PI103 )
Catalog No. M14282 CAS No. 371935-74-9
A potent, dual class I PI3K/mTOR inhibitor with IC50 of 2/3/3/15/ for p110α/β/δ/γ, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 47 | In Stock |
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| 10MG | 58 | In Stock |
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| 25MG | 113 | In Stock |
|
| 50MG | 185 | In Stock |
|
| 100MG | 340 | In Stock |
|
| 200MG | 518 | In Stock |
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| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePI-103
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, dual class I PI3K/mTOR inhibitor with IC50 of 2/3/3/15/ for p110α/β/δ/γ, respectively.
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DescriptionA potent, dual class I PI3K/mTOR inhibitor with IC50 of 2/3/3/15/ for p110α/β/δ/γ, respectively; also inhibits TORC1 (>80% inhibition at 0.5 uM) and DNA-PK (IC50=14 nM), 15- to 20-fold less activity against class II PI3K C2β (IC50=43 nM), >1,300-fold selectivity over the class III PI3K Vsp34; potently inhibits proliferation and invasion of a wide variety of human cancer cells in vitro; shows activity in cancer xenograft models.
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SynonymsPI 103;PI103
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PathwayPI3K/Akt/mTOR signaling
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TargetPI3K
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RecptorDNA-PK;p110α;p110β;p110γ;p110δ;mTOR
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number371935-74-9
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Formula Weight348.36
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Molecular FormulaC19H16N4O3
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESOC1=CC(=CC=C1)C1=NC2=C(OC3=C2C=CC=N3)C(=N1)N1CCOCC1 |c:3,5,13,16,18,21,t:1,8,10|
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Chemical NamePhenol, 3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Fan QW, et al. Cancer Cell. 2006 May;9(5):341-9.
2. Raynaud FI, et al. Cancer Res. 2007 Jun 15;67(12):5840-50.
3. Fan QW, et al. Cancer Res. 2007 Sep 1;67(17):7960-5.
4. Kojima K, et al. Leukemia. 2008 Sep;22(9):1728-36.
2. Raynaud FI, et al. Cancer Res. 2007 Jun 15;67(12):5840-50.
3. Fan QW, et al. Cancer Res. 2007 Sep 1;67(17):7960-5.
4. Kojima K, et al. Leukemia. 2008 Sep;22(9):1728-36.
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