PHTPP ( PHTPP )

Catalog No. M16016 CAS No. 805239-56-9

A potent, selective antagonist of estrogen ERβ receptor; exhibits 36-fold selective for ERβ, and is fully effective as an ERα antagonist.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Size	Price / USD	Stock	Quantity
2MG	34	In Stock
5MG	55	In Stock
10MG	84	In Stock
25MG	164	In Stock
50MG	267	In Stock
100MG	413	In Stock
500MG	888	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

PHTPP
Note

Research use only, not for human use.
Brief Description

A potent, selective antagonist of estrogen ERβ receptor; exhibits 36-fold selective for ERβ, and is fully effective as an ERα antagonist.
Description

A potent, selective antagonist of estrogen ERβ receptor; exhibits 36-fold selective for ERβ, and is fully effective as an ERα antagonist, while exhibiting no significant agonism on ERβ or Erα; enhances SKOV3 and OV2008 ovarian cancer cell growth in in vitro assays.
Synonyms

PHTPP
Pathway

Endocrinology/Hormones
Target

Estrogen Receptor/ERR
Recptor

ERβ
Research Area

Cancer
Indication

——

Chemical Information

CAS Number

805239-56-9
Formula Weight

423.30
Molecular Formula

C20H11F6N3O
Purity

>98% (HPLC)
Solubility

DMSO: 14 mg/mL (33 mM) （ < 1 mg/ml refers to the product slightly soluble or insoluble )
SMILES

OC1=CC=C(C2=C3N=C(C(F)(F)F)C=C(C(F)(F)F)N3N=C2C4=CC=CC=C4)C=C1
Chemical Name

4-[2-Phenyl-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]phenol

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Compton DR, et al. J Med Chem. 2004 Nov 18;47(24):5872-93.
2. Chan KK, et al. J Endocrinol. 2014 May 12;221(2):325-36.
3. Kajta M, et al. Neuroscience. 2013 May 15;238:345-60.

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