Cart
sales@molnova.com
(Z)-4-Hydroxytamoxifen
CAS No. 68047-06-3
(Z)-4-Hydroxytamoxifen( trans-4-Hydroxytamoxifen )
Catalog No. M15596 CAS No. 68047-06-3
A major metabolite of tamoxifen, a well-known Estrogen receptor antagonist in breast but partial estrogen receptor agonist in endometrium.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 58 | In Stock |
|
| 10MG | 80 | In Stock |
|
| 25MG | 177 | In Stock |
|
| 50MG | 347 | In Stock |
|
| 100MG | 512 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product Name(Z)-4-Hydroxytamoxifen
-
NoteResearch use only, not for human use.
-
Brief DescriptionA major metabolite of tamoxifen, a well-known Estrogen receptor antagonist in breast but partial estrogen receptor agonist in endometrium.
-
DescriptionA major metabolite of tamoxifen, a well-known Estrogen receptor antagonist in breast but partial estrogen receptor agonist in endometrium; shows a 100-fold increased affinity for ER and approximately 100-times more potent than trans-tamoxifen in suppressing cell growth and plasminogen activator activity.
-
In Vitro——
-
In Vivo——
-
Synonymstrans-4-Hydroxytamoxifen
-
PathwayEndocrinology/Hormones
-
TargetEstrogen Receptor/ERR
-
RecptorER
-
Research AreaCancer
-
Indication——
Chemical Information
-
CAS Number68047-06-3
-
Formula Weight387.5139
-
Molecular FormulaC26H29NO2
-
Purity>98% (HPLC)
-
SolubilityDMSO: ≥ 28 mg/mL
-
SMILESOC1=CC=C(/C(C2=CC=C(OCCN(C)C)C=C2)=C(C3=CC=CC=C3)\CC)C=C1
-
Chemical NamePhenol, 4-[(1Z)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]-
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Katzenellenbogen BS, et al. Cancer Res. 1984 Jan;44(1):112-9.
2. Desta Z, et al. J Pharmacol Exp Ther. 2004 Sep;310(3):1062-75.
3. Crewe HK, et al. Drug Metab Dispos. 2002 Aug;30(8):869-74.
molnova catalog
related products
-
4,4-Iminodiphenol
4,4'-Iminodiphenol is an inactive estrogen receptor ligand with a diphenylamine backbone.
-
4',7-Dimethoxyisofla...
4', 7-dimethoxyisoflavone, a kind of isoflavonoids, showed inhibitory effects on rat prostate testosterone 5α-reductase.
-
5Beta-Pregnane-3Alph...
An inactive metabolite of progesterone by reduction at C5, C3, and C20 position.
