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Home - Products - Endocrinology/Hormones - Estrogen Receptor/ERR - (Z)-4-Hydroxytamoxifen

(Z)-4-Hydroxytamoxifen

CAS No. 68047-06-3

(Z)-4-Hydroxytamoxifen( trans-4-Hydroxytamoxifen )

Catalog No. M15596 CAS No. 68047-06-3

A major metabolite of tamoxifen, a well-known Estrogen receptor antagonist in breast but partial estrogen receptor agonist in endometrium.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    (Z)-4-Hydroxytamoxifen
  • Note
    Research use only, not for human use.
  • Brief Description
    A major metabolite of tamoxifen, a well-known Estrogen receptor antagonist in breast but partial estrogen receptor agonist in endometrium.
  • Description
    A major metabolite of tamoxifen, a well-known Estrogen receptor antagonist in breast but partial estrogen receptor agonist in endometrium; shows a 100-fold increased affinity for ER and approximately 100-times more potent than trans-tamoxifen in suppressing cell growth and plasminogen activator activity.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    trans-4-Hydroxytamoxifen
  • Pathway
    Endocrinology/Hormones
  • Target
    Estrogen Receptor/ERR
  • Recptor
    ER
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    68047-06-3
  • Formula Weight
    387.5139
  • Molecular Formula
    C26H29NO2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 28 mg/mL
  • SMILES
    OC1=CC=C(/C(C2=CC=C(OCCN(C)C)C=C2)=C(C3=CC=CC=C3)\CC)C=C1
  • Chemical Name
    Phenol, 4-[(1Z)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Katzenellenbogen BS, et al. Cancer Res. 1984 Jan;44(1):112-9. 2. Desta Z, et al. J Pharmacol Exp Ther. 2004 Sep;310(3):1062-75. 3. Crewe HK, et al. Drug Metab Dispos. 2002 Aug;30(8):869-74.
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