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PHA-408
CAS No. 503555-55-3
PHA-408( PHA-767408 | PHA767408 | PHA 408 )
Catalog No. M14711 CAS No. 503555-55-3
A novel potent, highly selective, ATP-competitive IKK-2 inhibitor with IC50 of 40 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 262 | Get Quote |
|
| 50MG | 1152 | Get Quote |
|
| 100MG | 1746 | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NamePHA-408
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NoteResearch use only, not for human use.
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Brief DescriptionA novel potent, highly selective, ATP-competitive IKK-2 inhibitor with IC50 of 40 nM.
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DescriptionA novel potent, highly selective, ATP-competitive IKK-2 inhibitor with IC50 of 40 nM, 350-fold selectivity over IKK-1; inhibits LPS-induces TNF-α producton in PBMCs and HWB with IC50 of 20-30 nM, prevents IL-1β-induced IκBα phosphorylation in RASFs while sparing the JNK and p38 MAPK pathways and has no effect on IKK-2 phosphorylation; demonstrates target-specific anti-inflammatory activities in in vivo model of airway inflammation.
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In Vitro——
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In Vivo——
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SynonymsPHA-767408 | PHA767408 | PHA 408
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PathwayImmunology/Inflammation
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TargetIκB kinase (IKK)
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RecptorIκB kinase (IKK)
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Research AreaInflammation/Immunology
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Indication——
Chemical Information
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CAS Number503555-55-3
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Formula Weight560.03
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Molecular FormulaC29H27ClFN7O2
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(C1=NN(C2=CC=C(F)C=C2)C3=C1CCC4=CC=C(NC(C5=C(Cl)C=NC(N6CCN(C)CC6)=C5)=O)C=C43)N
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Chemical Name8-[[[5-Chloro-2-(4-methyl-1-piperazinyl)-4-pyridinyl]carbonyl]amino]-1-(4-fluorophenyl)-4,5-dihydro-1H-benz[g]indazole-3-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Mbalaviele G, et al. J Pharmacol Exp Ther. 2009 Apr;329(1):14-25.
2. Sommers CD, et al. J Pharmacol Exp Ther. 2009 Aug;330(2):377-88.
3. Xie J, et al. Bioorg Med Chem. 2011 Feb 1;19(3):1242-55.
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