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Home - Products - Chromatin/Epigenetic - Histone Demethylase - PF-9363

PF-9363

CAS No. 2569009-58-9

PF-9363( CTX-3648 )

Catalog No. M24156 CAS No. 2569009-58-9

PF-9363 is a potent and high selective KAT6A/KAT6B inhibitor. PF-9363 can be used for the research of cancer.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    PF-9363
  • Note
    Research use only, not for human use.
  • Brief Description
    PF-9363 is a potent and high selective KAT6A/KAT6B inhibitor. PF-9363 can be used for the research of cancer.
  • Description
    PF-9363 is a potent and high selective KAT6A/KAT6B inhibitor. PF-9363 can be used for the research of cancer.
  • In Vitro
    PF-9363 (0~1 μM; 1 day; ZR75-1, T47D and MCF7 cells) down-regulates the expression of H3K23Ac biomarker.PF-9363 leads to down regulation of a specific set of genes involved in ESR1 pathway, cell cycle and stem cell pathways. PF-9363 shows that the IC50 values for ZR75-1 and T47D are 0.3 nM and 0.9 nM. Western Blot Analysis Cell Line:ZR75-1, T47D and MCF7 cells Concentration:0~1 μM Incubation Time:1 day Result:Down-regulated the expression of H3K23Ac biomarker.
  • In Vivo
    PF-9363 shows strong anti-tumor activity in patient-derived xenograft models.
  • Synonyms
    CTX-3648
  • Pathway
    Chromatin/Epigenetic
  • Target
    Histone Demethylase
  • Recptor
    KAT6A/KAT6B
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2569009-58-9
  • Formula Weight
    444.46
  • Molecular Formula
    C20H20N4O6S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (112.50 mM)
  • SMILES
    O=S(C1=C(OC)C=CC=C1OC)(NC2=NOC3=C2C(OC)=CC(CN4N=CC=C4)=C3)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Shikhar S, et al. First-in-class KAT6A/KAT6B Inhibitor CTx-648 (PF-9363) Demonstrates Potent Anti-tumor Activity in ER+ Breast Cancer with KAT6A Dysregulation
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