PF-739 ( PF 739;PF739 )

Catalog No. M12861 CAS No. 1852452-14-2

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

PF-739
Note

Research use only, not for human use.
Brief Description

A novel potent, pan-AMPK activator with similar potency for all AMPK heterotrimers.
Description

A novel potent, pan-AMPK activator with similar potency for all AMPK heterotrimers; increases the phosphorylation of the AMPK substrate ACC at S79 with EC50 of 121 nM, potently inhibits de novo lipogenesis (IC50=25 nM) in primary rat hepatocytes; increases PGC1a transcription and mitochondrial content, effectively activats AMPK in hepatocytes and in skeletal muscle; caused a rapid lowering of plasma glucose levels with no impact on hepatic glucose production in diabetic mice.
Synonyms

PF 739;PF739
Pathway

Membrane Transporter/Ion Channel
Target

AMPK
Recptor

AMPK
Research Area

——
Indication

——

CAS Number

1852452-14-2
Formula Weight

442.90
Molecular Formula

C23H23ClN2O5
Purity

>98% (HPLC)
Solubility

——
SMILES

O[C@H]1[C@](OC[C@H]2OC3=NC4=CC(C5=CC=C(C6(CO)CC6)C=C5)=C(Cl)C=C4N3)([H])[C@]2([H])OC1
Chemical Name

(3R,3aR,6R,6aR)-6-((6-chloro-5-(4-(1-(hydroxymethyl)cyclopropyl)phenyl)-1Hbenzo[d]imidazol-2-yl)oxy)hexahydrofuro[3,2-b]furan-3-ol

1. Cokorinos EC, et al. Cell Metab. 2017 May 2;25(5):1147-1159.

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