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PF-06885249
CAS No. 1467059-70-6
PF-06885249( PF06885249 )
Catalog No. M12001 CAS No. 1467059-70-6
PF-06885249 (PF06885249) is a potent, direct AMPK activator with EC50 of 7.0 and 27 nM for α1β1γ1 and α2β1γ1, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 114 | Get Quote |
|
| 5MG | 192 | Get Quote |
|
| 10MG | 282 | Get Quote |
|
| 25MG | 480 | Get Quote |
|
| 50MG | 691 | Get Quote |
|
| 100MG | 972 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NamePF-06885249
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NoteResearch use only, not for human use.
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Brief DescriptionPF-06885249 (PF06885249) is a potent, direct AMPK activator with EC50 of 7.0 and 27 nM for α1β1γ1 and α2β1γ1, respectively.
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DescriptionPF-06885249 (PF06885249) is a potent, direct AMPK activator with EC50 of 7.0 and 27 nM for α1β1γ1 and α2β1γ1, respectively; displays no activity for α1β2γ1, α2β2γ1 and α2β2γ3 complexes (EC50>40 uM).
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In Vitro——
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In Vivo——
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SynonymsPF06885249
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PathwayMembrane Transporter/Ion Channel
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TargetAMPK
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RecptorAMPK
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Research Area——
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Indication——
Chemical Information
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CAS Number1467059-70-6
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Formula Weight345.783
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Molecular FormulaC17H16ClN3O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (289.20 mM)
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SMILESO=C(C1=CNC2=C1C=C(C3=CC=C(N(C)C)N=C3OC)C(Cl)=C2)O
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Chemical Name6-chloro-5-(6-(dimethylamino)-2-methoxypyridin-3-yl)-1H-indole-3-carboxylic acid
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Ryder T, et al. J Med Chem. 2018 Jul 23. doi: 10.1021/acs.jmedchem.8b00807.
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