Cart
sales@molnova.com
Home - Products - Microbiology/Virology - HIV - PF-46396

PF-46396

CAS No. 1207481-21-7

PF-46396( PF 46396 | PF46396 )

Catalog No. M10767 CAS No. 1207481-21-7

PF-46396 is a?specific small-molecule inhibitor of HIV-1 Gag maturation that interferes specifically with the cleavage of the CA/SP1 (p25) Gag precursor to the mature CA (p24) protein.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 873 Get Quote
50MG 1782 Get Quote
100MG 2250 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    PF-46396
  • Note
    Research use only, not for human use.
  • Brief Description
    PF-46396 is a?specific small-molecule inhibitor of HIV-1 Gag maturation that interferes specifically with the cleavage of the CA/SP1 (p25) Gag precursor to the mature CA (p24) protein.
  • Description
    PF-46396 is a?specific small-molecule inhibitor of HIV-1 Gag maturation that interferes specifically with the cleavage of the CA/SP1 (p25) Gag precursor to the mature CA (p24) protein; exhibits antiviral activity against 17/27 HIV-1 clinical isolates with EC50s ranging from 0.005 to 7 uM and TI values ranging from 2 to 3,400.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    PF 46396 | PF46396
  • Pathway
    Microbiology/Virology
  • Target
    HIV
  • Recptor
    HIV
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1207481-21-7
  • Formula Weight
    454.537
  • Molecular Formula
    C27H29F3N2O
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C1C(C(F)(F)F)=CC=CN1CC(C2=CC=C(C(C)(C)C)C=C2)NC3CC4=C(C=CC=C4)C3
  • Chemical Name
    1-[2-(4-tert-butylphenyl)-2-(2,3-dihydro-1H-inden-2-ylamino)ethyl]-3-(trifluoromethyl)pyridin-2-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Blair WS, et al. Antimicrob Agents Chemother. 2009 Dec;53(12):5080-7. 2. Murgatroyd C, et al. J Virol. 2016 Aug 26;90(18):8181-97. 3. Waki K, et al. PLoS Pathog. 2012;8(11):e1002997.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • YIR-821

    YIR-821 is a small-molecule CD4 mimic that acts as a highly potent HIV entry inhibitor with IC50 of 2.8 uM against YTA48P virus with no significant cytotoxicity (CC50>200 uM).

  • BMS-986001

    A thymidine analogue nucleoside reverse transcriptase inhibitor (NRTI) that inhibits HIV-2 isolates from treatment-naive individuals with EC50 of 30-81 nM.

  • Elvitegravir

    Elvitegravir (GS-9137, JTK-303) is an HIV integrase inhibitor for HIV-1 IIIB, HIV-2 EHO and HIV-2 ROD with IC50 of 0.7 nM, 2.8 nM and 1.4 nM in cell-free assays, respectively.

Sign In Join Free