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BMS-986001

CAS No. 634907-30-5

BMS-986001 ( BMS 986001;Censavudine;Festinavir;OBP-601;4'-Ed4T )

Catalog No. M15398 CAS No. 634907-30-5

A thymidine analogue nucleoside reverse transcriptase inhibitor (NRTI) that inhibits HIV-2 isolates from treatment-naive individuals with EC50 of 30-81 nM.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    BMS-986001
  • Note
    Research use only, not for human use.
  • Brief Description
    A thymidine analogue nucleoside reverse transcriptase inhibitor (NRTI) that inhibits HIV-2 isolates from treatment-naive individuals with EC50 of 30-81 nM.
  • Description
    A thymidine analogue nucleoside reverse transcriptase inhibitor (NRTI) that inhibits HIV-2 isolates from treatment-naive individuals with EC50 of 30-81 nM; inhibits isolates of HIV-1 with EC50 of 450-890 nM, also exhibits full activity against HIV-2 variants whose genomes encoded the single amino acid changes K65R and Q151M in reverse transcriptase.HIV Infection Phase 2 Clinical
  • Synonyms
    BMS 986001;Censavudine;Festinavir;OBP-601;4'-Ed4T
  • Pathway
    Microbiology/Virology
  • Target
    HIV
  • Recptor
    HIV
  • Research Area
    Infection
  • Indication
    HIV Infection

Chemical Information

  • CAS Number
    634907-30-5
  • Formula Weight
    248.24
  • Molecular Formula
    C12H12N2O4
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C1NC(C(C)=CN1[C@@H]2O[C@@](CO)(C#C)C=C2)=O
  • Chemical Name
    1-[(2R,5R)-5-ethynyl-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]-5-methylpyrimidine-2,4(1H,3H)-dione

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Li Z, et al. Antimicrob Agents Chemother. 2013 Nov;57(11):5500-8.
2. Wang F, et al. Antimicrob Agents Chemother. 2013 Dec;57(12):6205-12.
3. Smith RA, et al. Antimicrob Agents Chemother. 2015 Dec;59(12):7437-46.
4. Gupta SK, et al. Lancet HIV. 2016 Jan;3(1):e13-22.
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