PF-3450074

CAS No. 1352879-65-2

PF-3450074 ( PF3450074;PF-74;PF74 )

Catalog No. M11434 CAS No. 1352879-65-2

PF-3450074 (PF74) is a small molecule HIV capsid protein, destabilized the viral capsid in vitro; acts at an early stage of HIV-1 infection and inhibits reverse transcription in target cells.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 39 Get Quote
10MG 71 Get Quote
25MG 120 Get Quote
50MG 203 Get Quote
100MG 357 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    PF-3450074
  • Note
    Research use only, not for human use.
  • Brief Description
    PF-3450074 (PF74) is a small molecule HIV capsid protein, destabilized the viral capsid in vitro; acts at an early stage of HIV-1 infection and inhibits reverse transcription in target cells.
  • Description
    PF-3450074 (PF74) is a small molecule HIV capsid protein, destabilized the viral capsid in vitro; acts at an early stage of HIV-1 infection and inhibits reverse transcription in target cells, induced the rapid dissolution of the HIV-1 capsid; PF74 antiviral activity is promoted by binding of the host protein cyclophilin A to the HIV-1 capsid, and PF74 and cyclosporine exhibited mutual antagonism.
  • Synonyms
    PF3450074;PF-74;PF74
  • Pathway
    Microbiology/Virology
  • Target
    HIV
  • Recptor
    HIV
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1352879-65-2
  • Formula Weight
    425.53
  • Molecular Formula
    C27H27N3O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(N[C@@H](CC1=CC=CC=C1)C(N(C)C2=CC=CC=C2)=O)CC3=C(C)NC4=C3C=CC=C4
  • Chemical Name
    2-Methyl-N-[(1S)-2-(methylphenylamino)-2-oxo-1-(phenylmethyl)ethyl]- 1H-indole-3-acetamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Shi J, et al. J Virol. 2011 Jan;85(1):542-9.
2. Shi J, et al. J Virol. 2015 Jan;89(1):208-19.
3. Zhou J, et al. J Virol. 2015 Sep;89(17):9068-79.
4. Saito A, et al. J Virol. 2016 May 27;90(12):5808-5823.
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