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Home - Products - Microbiology/Virology - HIV - PF-3450074

PF-3450074

CAS No. 1352879-65-2

PF-3450074 ( PF3450074;PF-74;PF74 )

Catalog No. M11434 CAS No. 1352879-65-2

PF-3450074 (PF74) is a small molecule HIV capsid protein, destabilized the viral capsid in vitro; acts at an early stage of HIV-1 infection and inhibits reverse transcription in target cells.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    PF-3450074
  • Note
    Research use only, not for human use.
  • Brief Description
    PF-3450074 (PF74) is a small molecule HIV capsid protein, destabilized the viral capsid in vitro; acts at an early stage of HIV-1 infection and inhibits reverse transcription in target cells.
  • Description
    PF-3450074 (PF74) is a small molecule HIV capsid protein, destabilized the viral capsid in vitro; acts at an early stage of HIV-1 infection and inhibits reverse transcription in target cells, induced the rapid dissolution of the HIV-1 capsid; PF74 antiviral activity is promoted by binding of the host protein cyclophilin A to the HIV-1 capsid, and PF74 and cyclosporine exhibited mutual antagonism.
  • Synonyms
    PF3450074;PF-74;PF74
  • Pathway
    Microbiology/Virology
  • Target
    HIV
  • Recptor
    HIV
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1352879-65-2
  • Formula Weight
    425.53
  • Molecular Formula
    C27H27N3O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(N[C@@H](CC1=CC=CC=C1)C(N(C)C2=CC=CC=C2)=O)CC3=C(C)NC4=C3C=CC=C4
  • Chemical Name
    2-Methyl-N-[(1S)-2-(methylphenylamino)-2-oxo-1-(phenylmethyl)ethyl]- 1H-indole-3-acetamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Shi J, et al. J Virol. 2011 Jan;85(1):542-9.
2. Shi J, et al. J Virol. 2015 Jan;89(1):208-19.
3. Zhou J, et al. J Virol. 2015 Sep;89(17):9068-79.
4. Saito A, et al. J Virol. 2016 May 27;90(12):5808-5823.
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