Cart
sales@molnova.com
PF-06679142
CAS No. 1467059-66-0
PF-06679142( PF06679142 )
Catalog No. M12000 CAS No. 1467059-66-0
PF-06679142 is a novel potent, orally active, α1β1γ1/α2β1γ1-isoform selective AMPK activator with Kd of 14 nM, EC50 of 22 nM for α1β1γ1-AMPK.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 1053 | In Stock |
|
| 50MG | 2142 | In Stock |
|
| 100MG | 2790 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NamePF-06679142
-
NoteResearch use only, not for human use.
-
Brief DescriptionPF-06679142 is a novel potent, orally active, α1β1γ1/α2β1γ1-isoform selective AMPK activator with Kd of 14 nM, EC50 of 22 nM for α1β1γ1-AMPK.
-
DescriptionPF-06679142 is a novel potent, orally active, α1β1γ1/α2β1γ1-isoform selective AMPK activator with Kd of 14 nM, EC50 of 22 nM for α1β1γ1-AMPK, shows minimal activity at the β2-containing isoforms (α1β2γ1, α2β2γ1, α2β2γ3); demonstrates in vivo target engagement experiment in ZSF-1 rats, an obese/diabetic rodent model of diabetic nephropathy.
-
In Vitro——
-
In Vivo——
-
SynonymsPF06679142
-
PathwayMembrane Transporter/Ion Channel
-
TargetAMPK
-
RecptorAMPK
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1467059-66-0
-
Formula Weight357.357
-
Molecular FormulaC20H17F2NO3
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESO=C(C1=CNC2=C1C(F)=C(C3=CC=C([C@@H]4CCCCO4)C=C3)C(F)=C2)O
-
Chemical Name(S)-4,6-difluoro-5-(4-(tetrahydro-2H-pyran-2-yl)phenyl)-1H-indole-3-carboxylic acid
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Edmonds DJ, et al. J Med Chem. 2018 Feb 28. doi: 10.1021/acs.jmedchem.7b01641.
molnova catalog
related products
-
ZLN 024 hydrochlorid...
ZLN 024 hydrochloride is an AMPK allosteric activator and stimulates the inactive α1 subunit truncations α1 (1-394) and α1 (1-335) but not α1 (1-312).
-
Chitosan oligosaccha...
Chitosan oligosaccharide, an oligomer of β-(1→4)-linked D-glucosamine, activates AMPK and inhibits inflammatory signaling pathways.
-
ZLN-024
A novel AMPK allosteric activator that has no effect on mitochondrial function or the ADP/ATP ratio; directly activate recombinant AMPK α1β1γ1 and its homologue α2β1γ1 with EC50 of 0.42 uM and 0.95 uM, respectively.
