![](../../files/images/goods/1467059-66-0.png)
PF-06679142
CAS No. 1467059-66-0
PF-06679142 ( PF06679142 )
Catalog No. M12000 CAS No. 1467059-66-0
PF-06679142 is a novel potent, orally active, α1β1γ1/α2β1γ1-isoform selective AMPK activator with Kd of 14 nM, EC50 of 22 nM for α1β1γ1-AMPK.
Purity : >98% (HPLC)
![](/themes/theme/en/images/pdf.png)
![](/themes/theme/en/images/pdf.png)
![](/themes/theme/en/images/pdf.png)
![](/themes/theme/en/images/pdf.png)
![](/themes/theme/en/images/pdf.png)
![](/themes/theme/en/images/pdf.png)
Size | Price / USD | Stock | Quantity |
5MG | 1053 | Get Quote |
![]() ![]() |
50MG | 2142 | Get Quote |
![]() ![]() |
100MG | 2790 | Get Quote |
![]() ![]() |
200MG | Get Quote | Get Quote |
![]() ![]() |
500MG | Get Quote | Get Quote |
![]() ![]() |
1G | Get Quote | Get Quote |
![]() ![]() |
Biological Information
-
Product NamePF-06679142
-
NoteResearch use only, not for human use.
-
Brief DescriptionPF-06679142 is a novel potent, orally active, α1β1γ1/α2β1γ1-isoform selective AMPK activator with Kd of 14 nM, EC50 of 22 nM for α1β1γ1-AMPK.
-
DescriptionPF-06679142 is a novel potent, orally active, α1β1γ1/α2β1γ1-isoform selective AMPK activator with Kd of 14 nM, EC50 of 22 nM for α1β1γ1-AMPK, shows minimal activity at the β2-containing isoforms (α1β2γ1, α2β2γ1, α2β2γ3); demonstrates in vivo target engagement experiment in ZSF-1 rats, an obese/diabetic rodent model of diabetic nephropathy.
-
SynonymsPF06679142
-
PathwayMembrane Transporter/Ion Channel
-
TargetAMPK
-
RecptorAMPK
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1467059-66-0
-
Formula Weight357.36
-
Molecular FormulaC20H17F2NO3
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESO=C(C1=CNC2=C1C(F)=C(C3=CC=C([C@@H]4CCCCO4)C=C3)C(F)=C2)O
-
Chemical Name(S)-4,6-difluoro-5-(4-(tetrahydro-2H-pyran-2-yl)phenyl)-1H-indole-3-carboxylic acid
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Edmonds DJ, et al. J Med Chem. 2018 Feb 28. doi: 10.1021/acs.jmedchem.7b01641.
molnova catalog
![](/themes/theme/en/images/ct.png)
![](/themes/theme/en/images/ct2.png)
related products
-
PF-06409577
PF-06409577(PF06409577, PF 6409577)is a potent, selective AMPK β1-containing isoforms activator with TR-FRET EC50 of 7.0 and 6.8 nM for α1β1γ1 and α2β1γ1, respectively.
-
ETC-1002
A small molecule regulator of lipid and carbohydrate metabolism that targets ACC (acetyl-CoA carboxylase) with IC50 of 29 uM.
-
Dorsomorphin
Dorsomorphin (BML-275, Compound C) is a potent, selective and reversible AMPK inhibitor with Ki of 109 nM.