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AMAROGENTIN

CAS No. 21018-84-8

AMAROGENTIN( —— )

Catalog No. M20171 CAS No. 21018-84-8

Amarogentin is mainly extracted from Swertia and Gentiana roots. It plays cemopreventive/therapeutic role during liver carcinogenesis through modulation of cell cycle and apoptosis

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    AMAROGENTIN
  • Note
    Research use only, not for human use.
  • Brief Description
    Amarogentin is mainly extracted from Swertia and Gentiana roots. It plays cemopreventive/therapeutic role during liver carcinogenesis through modulation of cell cycle and apoptosis
  • Description
    Amarogentin is mainly extracted from Swertia and Gentiana roots. It plays cemopreventive/therapeutic role during liver carcinogenesis through modulation of cell cycle and apoptosis.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Carbon tetrachloride (HY-Y0298)-induced liver fibrosis mice modelDosage:100 mg/kg Administration:p.o.Result:Decreased hepatic α-SMA and TGF-β1 expression.Inhibited phosphorylation of JNK, ERK, and p38.
  • Synonyms
    ——
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    AMPK
  • Recptor
    AMPK
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    21018-84-8
  • Formula Weight
    586.54
  • Molecular Formula
    C29H30O13
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:2 mg/mL?(3.4 mM)
  • SMILES
    [H][C@@]12CCOC(=O)C1=CO[C@@H](O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1OC(=O)c1c(O)cc(O)cc1-c1cccc(O)c1)[C@@H]2C=C
  • Chemical Name
    (11'-Biphenyl)-2-carboxylic acid 33'5-trihydroxy- 2-ester with 5-ethenyl-6-(beta-D-glucopyranosyloxy)-44a56-tetrahydro-1H3H-pyrano(34-c)pyran-1-one (4aS-(4aalpha5beta6alpha))-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Shantanu S Khushboo B Durai S et al. The Bitter Barricading of Prostaglandin Biosynthesis Pathway: Understanding the Molecular Mechanism of Selective Cyclooxygenase-2 Inhibition by Amarogentin a Secoiridoid Glycoside from Swertia chirayita[J]. PLoS ONE 2014 9(3):e90637-.
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