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Home - Products - Immunology/Inflammation - IRAK - PF-06426779

PF-06426779

CAS No. 1817628-40-2

PF-06426779( PF06426779 )

Catalog No. M12792 CAS No. 1817628-40-2

PF-06426779 (PF06426779) is a potent, selective IRAK4 inhibitor with IC50 of 1 nM against full-length IRAK4 kinase and cell-based IC50 of 12 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    PF-06426779
  • Note
    Research use only, not for human use.
  • Brief Description
    PF-06426779 (PF06426779) is a potent, selective IRAK4 inhibitor with IC50 of 1 nM against full-length IRAK4 kinase and cell-based IC50 of 12 nM.
  • Description
    PF-06426779 (PF06426779) is a potent, selective IRAK4 inhibitor with IC50 of 1 nM against full-length IRAK4 kinase and cell-based IC50 of 12 nM; displays excellent selectivity against the human kinome, and >100-fold selectivity for IRAK4 over IRAK1.
  • In Vitro
    PF-06426779 inhibits IRAK4, with an IC50 of 12.7 nM in the peripheral blood mononuclear cells (PBMCs) assay.
  • In Vivo
    ——
  • Synonyms
    PF06426779
  • Pathway
    Immunology/Inflammation
  • Target
    IRAK
  • Recptor
    IRAK
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1817628-40-2
  • Formula Weight
    347.346
  • Molecular Formula
    C17H18FN3O4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (287.90 mM)
  • SMILES
    CC1C(NC(=O)C1F)COC2=NC=CC3=CC(=C(C=C32)OC)C(=O)N
  • Chemical Name
    1-(((2S,3S,4S)-4-Fluoro-3-methyl-5-oxopyrrolidin-2-yl)methoxy)-7-methoxyisoquinoline-6-carboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. De Nardo D, et al. J Biol Chem. 2018 Aug 3. pii: jbc.RA118.003314. 2. Lee KL, et al. J Med Chem. 2017 Jul 13;60(13):5521-5542.
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