Cart
sales@molnova.com
PF-05387252
CAS No. 1604034-71-0
PF-05387252( PF 05387252 | PF05387252 )
Catalog No. M12301 CAS No. 1604034-71-0
A potent, selective IRAK4 inhibitor with IC50 of 1.3 nM, 200-fold selectivity over IRAK1 (IC50=290 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NamePF-05387252
-
NoteResearch use only, not for human use.
-
Brief DescriptionA potent, selective IRAK4 inhibitor with IC50 of 1.3 nM, 200-fold selectivity over IRAK1 (IC50=290 nM).
-
DescriptionA potent, selective IRAK4 inhibitor with IC50 of 1.3 nM, 200-fold selectivity over IRAK1 (IC50=290 nM); exhibits low nM potency in LPS- and R848-induced cytokine assays (IC50=18 nM) in human PBMCs; inhibits LPS-induced TNFα in an in vivo murine model.
-
In Vitro——
-
In Vivo——
-
SynonymsPF 05387252 | PF05387252
-
PathwayImmunology/Inflammation
-
TargetIRAK
-
RecptorIRAK
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1604034-71-0
-
Formula Weight429.524
-
Molecular FormulaC25H27N5O2
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESN#CC1=CC(N2)=C(C3=C2C4=CC(OC)=C(OCCCN5CCN(C)CC5)C=C4N=C3)C=C1
-
Chemical Name11H-Indolo[3,2-c]quinoline-9-carbonitrile, 2-methoxy-3-[3-(4-methyl-1-piperazinyl)propoxy]-
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Lai CY, et al. J Immunol Res. 2017;2017:7807313.
2. Tumey LN, et al. Bioorg Med Chem Lett. 2014 May 1;24(9):2066-72.
molnova catalog
related products
-
PF-05387252
A potent, selective IRAK4 inhibitor with IC50 of 1.3 nM, 200-fold selectivity over IRAK1 (IC50=290 nM).
-
IRAK inhibitor 3
IRAK inhibitor 3 is an interleukin-1 (IL-1) receptor-associated kinase (IRAK) modulator.
-
IRAK4-IN-10
IRAK4-IN-10 (compound 75) is a potent IRAK4 inhibitor (IC50 = 1.5 nM) that can block the MyD88-dependent signaling pathway and has research potential in inflammatory diseases, autoimmune diseases, and cancer.
