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IRAK4-IN-16
CAS No. 509093-72-5
IRAK4-IN-16( IRAK4 inhibitor 16 )
Catalog No. M14747 CAS No. 509093-72-5
A potent, selective, and orally bioavailable inhibitor of interleukin-1 receptor-associate kinase-4 (IRAK4) with IC50 of 2.8 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameIRAK4-IN-16
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective, and orally bioavailable inhibitor of interleukin-1 receptor-associate kinase-4 (IRAK4) with IC50 of 2.8 nM.
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DescriptionA potent, selective, and orally bioavailable inhibitor of interleukin-1 receptor-associate kinase-4 (IRAK4) with IC50 of 2.8 nM, 217- and 892-fold selectivity over IRAK-1 and TAK1, respectively; inhibits IL-1 induced activation of NF-kB in primary human monocytes with IC50 of 0.3 uM, possesses excellent selectivity and pharmacokinetic properties.
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In Vitro——
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In Vivo——
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SynonymsIRAK4 inhibitor 16
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PathwayImmunology/Inflammation
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TargetIRAK
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RecptorIRAK
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Research Area——
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Indication——
Chemical Information
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CAS Number509093-72-5
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Formula Weight478.519
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Molecular FormulaC27H25F3N4O
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(NC1=NC2=CC(CN3CCCCC3)=CC=C2N1C4=CC=CC=C4)C5=CC=CC(C(F)(F)F)=C5
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Chemical NameN-(1-phenyl-5-(piperidin-1-ylmethyl)-1H-benzo[d]imidazol-2-yl)-3-(trifluoromethyl)benzamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Wang Z, et al. Bioorg Med Chem Lett. 2015 Dec 1;25(23):5546-50.
molnova catalog
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