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PF-04745637

CAS No. 1917294-46-2

PF-04745637( —— )

Catalog No. M26002 CAS No. 1917294-46-2

PF-04745637 is a potent and selective TRPA1 antagonist with an IC50 of 17 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    PF-04745637
  • Note
    Research use only, not for human use.
  • Brief Description
    PF-04745637 is a potent and selective TRPA1 antagonist with an IC50 of 17 nM.
  • Description
    PF-04745637 is a potent and selective TRPA1 antagonist with an IC50 of 17 nM.(In Vivo):PF-04745637 (topically applied; 50 mg/mL and 100 mg/mL) significantly reduces cinnamaldehyde-mediated flare in rat skin.
  • In Vitro
    ——
  • In Vivo
    Topically applied PF-04745637 (Compound 8; 50 mg/mL and 100 mg/mL) significantly reduces cinnamaldehyde-mediated flare in rat skin.
  • Synonyms
    ——
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    TRP/TRPV Channel
  • Recptor
    Immunology/Inflammation related
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1917294-46-2
  • Formula Weight
    509.01
  • Molecular Formula
    C27H32ClF3N2O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (245.58 mM)
  • SMILES
    OC1(CCN(CC1)C(CNC(=O)C1(CCCC1)c1ccc(Cl)cc1)Cc1ccccc1)C(F)(F)F
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Constituents of Compositae plants III. Anti-tumor promoting effects and cytotoxic activity against human cancer cell lines of triterpene diols and triols from edible chrysanthemum flowers.Cancer Lett., 2002, 177(1):7-12.
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